鼻腔鼻窦内翻性乳头状瘤中Fas、FasL及Bcl-2的表达

目的探讨细胞凋亡相关蛋白Fas、FasL在鼻腔鼻窦内翻性乳头状瘤(sinonasal inverted papilloma,SNIP)中的表达及其与Bcl-2表达的相关性。方法采用免疫组化法检测20例SNIP,10例鼻腔鳞状细胞癌及10例正常下鼻甲黏膜标本中Fas、FasL及Bcl-2的表达。结果SNIP和鼻腔鳞状细胞癌组织FasL阳性表达分别为65%和70%,显著强于正常下鼻甲黏膜组织(P均<0.01),而Fas阳性表达分别为25%和30%,均显著弱于下鼻甲组织(P均<0.01),差异均有统计学意义。FasL阳性表达强于Fas阳性表达。SNIP和鼻腔鳞状细胞癌组织中Bcl-2的表达分别为60%和90%,均显著高于正常下鼻甲黏膜组织(P均<0.01)。在SNIP组织中FasL表达与Bcl-2表达呈正相关(P<0.01),Fas与Bcl-2表达无相关性(P>0.05)。结论 Fas、FasL及Bcl-2在SNIP发生、发展中起重要作用。

Expression of Fas, FasL and Bcl-2 in sinonasal inverted papilloma

OBJECTIVE To investigate the expression of Fas and FasL and it＇s relationship with the expression of Bcl-2 in sinonasal inverted papilloma（SNIP）.METHODS Immunohistochemical method was used to determine the expression of Fas,FasL and Bcl-2 in 20 cases of SNIP,10 cases of sinonasal squamous cell carcinoma（SCC）and 10 cases of normal inferior concha tissues.RESULTS In the tissues of SNIP and SCC,the positive expression rates of FasL were 65%,70%,Expression of FasL was significantly higher in SNIP and SCC than in normal tissues,the positive expression rates of Fas were 25%,30%.Expression of Fas was significantly lower in SNIP and SCC than in normal tissues.The expression of FasL was significantly higher than Fas in SNIP and SCC.In the tissues of SNIP and SCC,the positive expression rates of Bcl-2 were 60%,90%.Expression of Bcl-2 was significantly higher in SNIP and SCC than in normal tissues.Expression of FasL was positively related to expression of Bcl-2 in SNIP.CONCLUSION Fas,FasL and Bcl-2 may play an important role in the pathway of progression of SNIP and SCC.