| 五甲基槲皮素对豚鼠心肌收缩力和电生理特性的影响 |
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| 引用本文： | 张晓华,刘祖梅,何婷,杨斐,金满文.五甲基槲皮素对豚鼠心肌收缩力和电生理特性的影响[J].华中科技大学学报(医学版),2008,37(6). |
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| 作者姓名： | 张晓华 刘祖梅 何婷 杨斐 金满文 |
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| 作者单位： | 华中科技大学同济医学院基础医学院药理学系,武汉,430030 |
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| 摘 要： | 目的比较研究五甲基槲皮素（PMQ）和槲皮素（QUE）对离体豚鼠心肌收缩力和电生理特性的影响并探讨其机制。方法测定离体豚鼠右心房肌自律性及左心房肌收缩力；同步记录豚鼠心乳头肌动作电位和收缩力；全细胞膜片钳技术记录豚鼠心室肌细胞L型钙电流（ICa.1）。结果10、30、100μmol／LPMQ和QUE均可增强左心房肌收缩力；PMQ对右心房自律性无明显作用，QUE则可提高右心房自律性。30、100μmol／LPMQ对豚鼠心乳头肌动作电位无明显影响，QUE可延长豚鼠心室肌动作电位时程；QUE增强乳头肌收缩力的作用强于PMQ。PMQ与QUE均抑制ICa.L，后者作用更强。结论PMQ与QUE均可增强豚鼠心肌收缩力；PMQ与QUE对豚鼠右心房自律性的作用趋势相反；PMQ对乳头肌动作电位无明显作用，对心室肌细胞ICa.L的抑制作用弱于QUE。首次揭示了PMQ在心脏方面的作用，为该类药物在临床的应用提供了有价值的参考信息。
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| 关 键 词： | 五甲基槲皮素 槲皮素 收缩力 动作电位 钙电流 |
Effects of Pentamethylquercetin on Contractility and Electrophysiology of Cardiac Muscle in Guinea Pigs |
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| Zhang Xiaohua,Liu Zumei,He Ting et al.Effects of Pentamethylquercetin on Contractility and Electrophysiology of Cardiac Muscle in Guinea Pigs[J].Journal of Huazhong University of Science and Technology(Health Sciences),2008,37(6). |
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| Authors: | Zhang Xiaohua Liu Zumei He Ting |
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| Institution: | Zhang Xiaohua,Liu Zumei,He Ting et al Department of Pharmacology,School of Basic Medical Sciences,Tongji Medical College,Huazhong University of Science , Technology,Wuhan 430030 |
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| Abstract: | Objective To investigate the effects of 3,3',4',5,7-pentamethylquercetin (PMQ) on contractility and electrophysiology of cardiac muscle in guinea pigs. Methods The effects of PMQ on contractility of left atrium and autorhythmicity of right atrium were investigated. Action potentials and contractility of isolated papillary muscle in guinea pigs were simultaneously examined by using standard microelectrode technique. The effects of PMQ on voltage-dependent L-type Ca2+ current of cardiomyocytes were assessed b... |
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| Keywords: | pentamethylquercetin quercetin contractility action potential calcium current |
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