高原地区眼球穿通伤患者体液免疫功能的变化

目的 了解高原地区眼球穿通伤患者体液免疫功能的变化。方法 采用单项琼脂免疫扩散法,选取海拔高度为3658m的地区51例（53只眼）眼球穿通伤患者为外伤组,同海拔高度移居适应者及世居者,身体健康的45人作为对照组,分别检测血清及泪液中IgG,IgA,gM,补体C3及C4的含量。结果 外伤组患者血清及泪液免疫球蛋白含量普遍升高,以IgA更为明显,伤后3d清免疫球蛋白含量升至最高,伤后7d泪液中免疫球蛋白含量升至最高,伤后15d血清免疫球蛋白含量已低于术前,但仍高于健康人（P＜0．05）,伤后15d泪液免疫球蛋白含量除IgA外,其他均低于术前,但高于健康人（P＜0．05）。血清及泪液补体C3,C4含量无明显改变（P＞0．05）。结论 高原地区眼球穿通伤后局部存在一定的感染因子,它在自身免疫反应中起着“左剂效应物”的作用,增强自身组织的抗原性而产生病理过程。

The change of immunoglobulin in patients with eyeball perforation at high altitude

Objective To explore the change of tear immune function on eyeballs with perforating injury at high altitude. Methods In 51 patients (53 eyes) with eyeball perforating injury at high altitude (sea level 3 658 m), by using single agar immune diffusion test, IgG, IgA, IgM, C 3 and C 4 values of tears were separately measured before and after clinical cure. Results The Ig values of tears increased universally. The IgA value increased especially in the 7th day. The IgG and IgM value in the serum increased in the 3rd day after injury ( P <0 05), and the IgG, IgA and IgM of tears increased especially on the 7th day ( P <0 01). The C 3 and C 4 value of tears did not change significantly ( P <0 05). Conclusions The change of Ig value is a useful detective means to evaluate the treatment effect.