| 咽喉鳞状细胞癌组织中HPV的检测 |
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| 引用本文： | 任景丽,王宪远,高冰,陈向东,常福聚. 咽喉鳞状细胞癌组织中HPV的检测[J]. 郑州大学学报(医学版), 1996, 0(3) |
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| 作者姓名： | 任景丽 王宪远 高冰 陈向东 常福聚 |
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| 作者单位： | 河南医科大学第二附属医院，河南职工医学院病理教研室，芬兰Ｋｕｏｐｉｏ大学癌前研究室 |
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| 摘 要： | 用免疫组化及ＤＮＡ斑点杂交技术检测人咽喉部鳞状细胞癌组织中ＨＰＶ壳蛋白抗原及ＨＰＶ６、１１、１６、１８型ＤＮＡ序列。４５例鳞状细胞癌组织ＨＰＶ抗原阳性率为２２．２％，ＨＰＶＤＮＡ阳性率为３１．１％，５例正常粘膜ＨＰＶ抗原及ＨＰＶＤＮＡ均阳性。结果提示咽喉部鳞状细胞癌的发生和发展与ＨＰＶ感染有关系。
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| 关 键 词： | 咽肿瘤；喉肿瘤；乳头状瘤病毒；DNA杂交 |
Detection of HPV structural antigens and DNA sequences in squamous cell carcinomas of the pharynx and larynx |
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| Ren Jingli,Wang Xianyuan,Gao Bing,Chen Xiangdong. Detection of HPV structural antigens and DNA sequences in squamous cell carcinomas of the pharynx and larynx[J]. Journal of Zhengzhou University: Med Sci, 1996, 0(3) |
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| Authors: | Ren Jingli Wang Xianyuan Gao Bing Chen Xiangdong |
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| Abstract: | Immunohistochemical staining and DNA dot blot hybridization were used to detect HPV structural antigens and HPV 6,11,16,18 DNA sequences in squamous cell carcinomas of the pharynx and larynx.HPV was negative in all normal mucosa (5 cascs).The positive rates of HPV structural antigens and HPV DNA sequences in 45 cases of squarnous cell carcinomas were 22.2%and 31.1% respectively. The results indicate that the squamous cell carcinomas of the pharynx and larynx may be related to HPV infection. |
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| Keywords: | pharynx tumor larynx tumor HPV DNA hybridization |
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