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Superior temporal gyrus spectral abnormalities in schizophrenia |
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| Authors: | Edgar J Christopher Hanlon Faith M Huang Ming-Xiong Weisend Michael P Thoma Robert J Carpenter Bruce Hoechstetter Karsten Cañive José M Miller Gregory A |
| Affiliation: | Department of Psychology, University of Illinois at Urbana–Champaign, Urbana, Illinois, USA; Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA; Center for Functional Brain Imaging, New Mexico VA Healthcare System, Albuquerque, New Mexico, USA; Department of Radiology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA; Department of Psychology, University of New Mexico, Albuquerque, New Mexico, USA; The MIND Institute, Albuquerque, New Mexico, USA; Department of Radiology, University of California, San Diego, California, USA; VA San Diego Healthcare System, San Diego, California, USA; Department of Radiology, University of New Mexico, Albuquerque, New Mexico, USA; Department of Mathematics, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA; MEGIS Software GmbH, Gräfelfing, Germany; Department of Psychiatry, University of New Mexico, Albuquerque, New Mexico, USA; Department of Psychiatry, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA |
| Abstract: | Considerable evidence indicates early auditory stimulus processing abnormalities in schizophrenia, but the mechanisms are unclear. The present study examined oscillatory phenomena during a paired-click paradigm in the superior temporal gyrus (STG) as a possible core problem. The primary question addressed is whether first click and/or second click group differences in the time-domain evoked response in patients with schizophrenia are due to (1) group differences in the magnitude of poststimulus oscillatory activity, (2) group differences in poststimulus phase-locking, and/or (3) group differences in the magnitude of ongoing background oscillatory activity. Dense-array magnetoencephalography from 45 controls and 45 patients with schizophrenia produced left- and right-hemisphere STG 50- and 100-ms time-frequency evoked, phase-locking, and total power measures. Whereas first click 100-ms evoked theta and alpha abnormalities were observed bilaterally, evoked low beta-band differences were specific to the left hemisphere. Compared to controls, patients with schizophrenia showed more low-frequency phase variability, and the decreased 100-ms S1 evoked response observed in patients was best predicted by the STG phase-locking measure. |
| Keywords: | Sensory gating Schizophrenia M50 M100 Evoked Phase-locking Magnetoencephalography |
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