头低位-6°卧床期间人体内分泌激素的变化

目的观察 7d卧床前中后血尿内分泌激素的变化。方法 6名男性被试者头低位 - 6°卧床条件下 ,测量卧床前 48h、卧床 48h、1 2 0h血中皮质醇 (CORT)、醛固酮 (ALD)、甲状腺素 (T3 、T4)含量 ;同时留取每天 6∶0 0～ 2 2∶0 0 ,2 2∶0 0～ 6∶0 0 2个时相的尿样 ,测定尿中CORT、ALD、儿茶酚胺 [去甲肾上腺素 (NE)、肾上腺素 (E)、多巴胺 (DA) ]等内分泌指标。结果被试者卧床 48h时血中的CORT、ALD上升 ,T3 、T4、总蛋白 (TP)、尿尿素氮 (UUN)下降 ;卧床 1 2 0h时 ,又恢复到卧床前水平。尿中的CORT、ALD及去甲肾上腺素在 2 4～ 48h达到最大值 ,以后逐渐回落到卧床前水平。结论血尿中主要内分泌指标随头低位- 6°卧床时间的延长逐渐恢复到正常水平

Changes of Endocrine Hormones during -6°Head Down Bed Rest in Human

Objective: To investigate changes of endocrine hormones during 7 d head down bed rest (HDBR). Method: Six healthy male volunteers served as the subjects and experienced 7 d -6 degrees HDBR. Urine was collected from 6:00-22:00 and from 22:00-6:00. Serum was collected 48 h before HDBR, 48 h and 120 h during HDBR. Then the endocrine indices in urine and serum were determined. Result: 1) The levels of serum CORT and ALD increased at 48 h during HDBR, while serum T3, T4, TP, UN decreased but they all recovered to normal at 120 h during HDBR. 2) The level of urine CORT, ALD and NE reached its peak in 24-48 h, and then gradually decreased to normal level. Conclusion: The endocrine indices in serum and urine changed in the early period but returned to normal level gradually with the proceeding of HDBR.