磁共振氨基质子转移成像的临床应用

磁共振氨基质子转移(amide proton transfer,APT)成像是一种基于化学交换饱和转移技术且可反映生物组织中内源性游离蛋白和肽类含量以及氨基质子交换速率的无创性分子磁共振成像方法。APT加权图像是通过对Z谱中水频率两侧±3.5 ppm处的非对称性磁化转移率进行计算得到的。近年来,APT磁共振成像(magnetic resonance imaging,MRI)已被越来越多地应用于疾病诊断中。本文针对目前APT MRI在临床应用和科学研究方面的进展予以综述。

Clinical applications of amide proton transfer magnetic resonance imaging

Amide proton transfer (APT) imaging is a noninvasive molecular magnetic resonance imaging (MRI) method based on chemical exchange dependent saturation transfer technique that detects endogenous mobile proteins and peptides, and amide proton exchange rates in biological tissues. APT weighted image is calculated by the magnetization transfer asymmetry between ±3.5 ppm which respect to the water frequency on z-spectrum. In recent years, APT MRI has been increasingly used for the diagnosis of diseases. In this article, we reviewed the developments of APT MRI in the clinical applications and scientific researches.