| 脑部化学交换饱和转移成像研究 |
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| 引用本文： | 杨永贵,沈智威,吴仁华,陈忠,蔡聪波,郭岗.脑部化学交换饱和转移成像研究[J].磁共振成像,2016,7(4):249-253. |
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| 作者姓名： | 杨永贵 沈智威 吴仁华 陈忠 蔡聪波 郭岗 |
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| 作者单位： | 厦门市第二医院医学影像科,厦门,361021;汕头大学医学院第二附属医院放射科,汕头,515041;厦门大学物理与机电工程学院，厦门大学电子科学系，福建省等离子体与磁共振研究重点实验室，厦门361005 |
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| 基金项目： | 2014年厦门市科技局科技惠民计划项目(编号:3502Z20144052)~~ |
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| 摘 要： | 化学交换饱和转移(chemical exchange saturation transfer,CEST)成像是在磁化传递及化学交换理论基础上发展起来的一种磁共振成像新方法,其扩展了磁共振分子影像新领域,但还处于研究阶段。其以细胞内物质为内源性对比剂,通过水信号间接检测代谢物信息,进行组织的酸碱度成像及其各种代谢物成像。本文主要探讨MRI领域中与水相关的化学交换饱和转移现象,阐述其原理、研究现状及其在不同场强磁共振仪上脑部疾病的应用。
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| 关 键 词： | 化学交换饱和转移 酰胺质子转移 酸碱度 脑肿瘤 脑梗死 |
Research of chemical exchange saturation transfer in brain |
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| YANG Yong-gui,SHEN Zhi-wei,WU Ren-hua,CHEN Zhong,CAI Cong-bo,GUO Gang.Research of chemical exchange saturation transfer in brain[J].Chinese Journal of Magnetic Resonance Imaging,2016,7(4):249-253. |
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| Authors: | YANG Yong-gui SHEN Zhi-wei WU Ren-hua CHEN Zhong CAI Cong-bo GUO Gang |
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| Institution: | YANG Yong-gui;SHEN Zhi-wei;WU Ren-hua;CHEN Zhong;CAI Cong-bo;GUO Gang;Department of medical imaging, The Second Hospital of Xiamen;Departmentof Radiology, The Second Affiliated Hospital of Shantou University Medical College;Physical and mechanical and Electrical Engineering College of Xiamen University,Xiamen University, Department of Electronic Science,Fujian Province Key Laboratory of plasma and magnetic resonance; |
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| Abstract: | Chemical exchange saturation transfer (CEST) imaging is a new method for magnetic resonance imaging theory of exchange in the magnetization transfer and chemical, the expansion of the new field of molecular magnetic resonance imaging, but it’s still in the research stage. The intracellular substances as an endogenous contrast agent, through the indirect detection of metabolite water signal information for tissue pH imaging and imaging of various metabolites. This paper mainly discusses the chemical and water exchange in the field of MRI saturation transfer phenomenon, expounds the principle, research status and the application in brain diseases used the different field strength clinical MRI scanner. |
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| Keywords: | Chemical exchange saturation transfer Amide proton transfer pH value Brain tumor Stroke |
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