Vascular type I aldosterone binding sites are physiological mineralocorticoid receptors |
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Authors: | J W Funder P T Pearce R Smith J Campbell |
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Affiliation: | Medical Research Centre, Prince Henry's Hospital, Melbourne, Victoria, Australia. |
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Abstract: | In vitro, Type I receptors have high and equivalent affinity for aldosterone, corticosterone and cortisol: in vivo, physiological mineralocorticoid target tissues (kidney, colon, parotid) are highly aldosterone-selective, in contrast with hippocampus and heart. In the present study we show that the mesenteric vascular arcade is similarly highly aldosterone-selective in vivo, and in vitro shows considerable levels of 11 beta OH steroid dehydrogenase activity, previously postulated as the mechanism whereby glucocorticoids are excluded from physiological mineralocorticoid receptors. |
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