Significance of rheumatoid factor isotypes in seronegative rheumatoid arthritis |
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Authors: | F. Eggelmeijer H. G. Otten H. H. de Rooy M. R. Daha F. C. Breedveld |
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Affiliation: | (1) Department of Rheumatology, University Hospital Leiden, NL-2300 Leiden, RC, The Netherlands;(2) Department of Nephrology, University Hospital Leiden, NL-2300 Leiden, RC, The Netherlands |
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Abstract: | Summary In a cross-sectional study of 124 patients with definite or classical rheumatoid arthritis (RA) and negative agglutination assays, rheumatoid factor (RF) isotypes were measured using an ELISA technique. Elevated levels of IgA-RF were found in 55 patients (44%), IgG-RF in 99 (80%), and IgM-RF in 20 (16%). The levels of IgA- and IgM-RF correlated with each other (P<0.001). Elevated levels of IgM-RF were associated with a more severe disease course. Elevated levels of IgA-RF correlated with the occurrence of bone erosions. The results of this study suggest that in patients with RA and negative agglutination assays, both IgM- and IgA-RF are markers of disease severity. |
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Keywords: | Rheumatoid factor Seronegative rheumatoid arthritis ELISA Bone erosions |
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