住院患者初治、复治痰培养阳性肺结核耐药性分析

目的:分析初、复治肺结核耐药性异同点,探讨耐药肺结核的预防与控制。方法:对2007年11月~2009年12月578例痰快速培养阳性住院患者中的213例耐药患者按初、复治分组进行回顾性分析。结果:初治组总耐药率为29.2%,复治组为53.3%,总耐药率初治组小于复治组,差异有统计学意义(P<0.01);初治组单耐药率为13.2%,单耐H6.6%(单耐S 4.8%(单耐E1.0%(单耐R0.8%,复治组单耐药率为16.3%,复治组单耐H11.4%(单耐S2.7%(单耐E1.1%、单耐R1.1%,单耐药率初复治组差异无统计学意义;初治组耐多药率为7.1%,耐HRS 3.3%>耐HRES 2.0%(耐HR 1.5%(耐HRE 0.3%,复治组耐多药率为29.9%,耐HRES 13.6%(耐HRS 9.8%(耐HR 6.0%(耐HRE 0.5%,耐多药率初治组小于复治组,差异有统计学意义(P<0.05);初治组多耐药率为8.9%,初治组耐HS(7.1%)(耐RS(0.5%)、耐RES(0.5%)(耐HE(0.3%)、耐HES(0.3%)、耐SE(0.3%),复治组多耐药率为7.1%,耐HS(5.4%)(耐HE(1.1%)(耐RS(0.5%),多耐药率初复治组差异无统计学意义。结论:单耐药中均以耐H最高,耐R最低,耐多药率初治组小于复治组,多耐药率均以耐HS最多。

Analysis of drug resistance on initial treatment and retreatment pulmonary tuberculosis patients in hospital

Objective To analyze the difference of drug resistance of initial treatment and retreatment pulmonary tuberculosis,approach drugfast phthisical prevention and control.Method For 213 drugfast patients from 578 hospital patients with quick culture positive during November 2007 and December 2009 were divided into two groups according to initial treatment and retreatment,and made retrospective analysis.Results The total resistant rate in the initial treatment group is 29.2%,in the retreatment group is 53.3%,the difference between the two groups is statistically significant（P0.01）;the resistant rate to one drug in the initial treatment group is 13.2%,the resistant rate to H（6.6%）﹥the resistant rate to S（4.8%）﹥the resistant rate to E（1.0%）﹥the resistant rate to R（0.8%）;the resistant rate to one drug in the retreatment group is 16.3%,the resistant rate to H（11.4%）﹥the resistant rate to S（2.7%）﹥the resistant rate to E（1.1%）,the resistant rate to R（1.1%）;the difference of the resistant rate to one drug in the two groups is not statistically significant;the multidrug resistance rate in the initial treatment group is 7.1%,the resistant rate to HRS（3.3%）﹥the resistant rate to HRES（2.0%）﹥the resistant rate to HR（1.5%）﹥the resistant rate to HRE（0.3%）;the multidrug resistance rate in the retreatment group is 29.9%,the resistant rate to HRES（13.6%）﹥the resistant rate to HRS（9.8%）﹥the resistant rate to HR（6.0%）﹥the resistant rate to HRE（0.5%）,the difference of multidrug resistance rate in the two groups is statistically significant（P0.05）;the polyresistance rate in the initial treatment group is 8.9%,the resistant rate to HS（7.1%）﹥the resistant rate to RS（0.5%）,the resistant rate to RES（0.5%）﹥the resistant rate to HE（0.3%）,the resistant rate to HES（0.3%）,the resistant rate to SE（0.3%）,the polyresistance rate in the retreatment group is 7.1%,the resistant rate to HS（5.4%）﹥the resistant rate to HE（1.1%）﹥the resistant rate to RS（0.5%）,the difference of polyresistance rate in the two groups is not statistically significant.Conclusion The resistant rate only to H is the highest in the two groups,the resistant rate only to R is the lowest in the two groups,multidrug resistance rate in the initial treatment group is lower than that in the retreatment group.The resistant rate to HS in polyresistance tuberculosis is the highest in the two groups.