Interferon-alpha therapy in atopic dermatitis. |
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| Authors: | A Torrelo A Harto E Sendagorta B M Czarnetzki A Ledo |
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| Affiliation: | Department of Dermatology, Hospital Ramón y Cajal, Madrid, Spain. |
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| Abstract: | Thirteen patients with a severe adult form of atopic dermatitis (AD) received 3.0 x 10(6) IU of recombinant interferon-alpha 2a (rIFN-alpha 2a) 3 times a week. A satisfactory response was obtained in 5 of them. Serum IgE levels in all 13 patients remained unchanged throughout the study. Flu-like symptoms were common, but clinical or laboratory adverse effects were otherwise slight. The moderately beneficial therapeutic effects observed in this study support a possible role for IFN-alpha in controlling immunologic deficiencies in atopic dermatitis. |
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