The novel gluconeogenesis inhibitor FR225654 that originates from Phoma sp. no. 00144. I. Taxonomy, fermentation, isolation and physico-chemical properties |
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| Authors: | Ohtsu Yoshihiro Sasamura Hiromi Tanaka Miho Tsurumi Yasuhisa Yoshimura Seiji Takase Shigehiro Shibata Toshihiro Hino Motohiro Nakajima Hidenori |
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| Affiliation: | Fermentation Research Laboratories, Fujisawa Pharmaceutical Co, Ltd. yoshihiro.ohtsu@jp.astellas.com |
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| Abstract: | FR225654, a novel gluconeogenesis inhibitor, was isolated from the culture broth of Phoma sp. No. 00144 and purified by adsorptive resin and reverse-phase column chromatography. This compound is a potent inhibitor of gluconeogenesis and is a promising candidate of anti-diabetic agent. |
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