吡喹酮治疗人体肝,肺包虫病的观察

OBSERVATION ON THE PRAZIQUANTEL TREATMENT OF HUMAN HYDATID DISEASE

The concentration of praziquantel was assayed and the changes of fine structures of the greminal layer and the protoscoleces of hydatid cysts were studied from 25 patients with lung or liver hydatid disease who underwent surgery after 7-day medication with a total dose of 300mg praziquantel therapy. Our results definitely indicate that praziquantel can be found in the hydatid cysts wall and its fluid but it is very low. The drug level in cyst walls and fluid in the pulmonary group is lower than that in the hepatic group, although the level in blood is similar for both groups. This difference co-incided with the better results in treatment of hepatid hydatid disease. In the treated group both in the hepatic and pulmonary cysts the greminal layer showed that the number of vacules increased but decreased in mitochondria, golgi complex, rough endoplasmic reticulum and glycogen, more lysosome and myelinoid body were observed in the cytoplasm of tegument cells. Most of the protoscoleces evaginated and suckers protruded.The tegument surface of the rear part was obviously damaged. It is confirmed, therefore, that praziquantel is of protoscolicidal effect in the treatment of hydatid disease and the mortality of the protoscoleces in hepatic cysts is higher than that in the pulmonary cysts in the treated group.