| 卵巢癌中多药耐药基因的表达及其意义 |
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| 引用本文： | 张帆,陈惠祯,刘诗权,杨庆忆.卵巢癌中多药耐药基因的表达及其意义[J].医学新知杂志,2001,11(2):80-81. |
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| 作者姓名： | 张帆 陈惠祯 刘诗权 杨庆忆 |
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| 作者单位： | 武汉大学中南医院肿瘤科武汉 430071 |
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| 基金项目： | 湖北省科委重点科技攻关项目资助!(编号 :95 1P160 2 ) |
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| 摘 要： | 为探讨卵巢癌隐含的耐药机制及其对化疗的影响，用RT－PCR方法对7例正常卵巢组织及32例卵巢癌进行了多药耐药基因（mdr1)检测，结果表明：正常卵巢组织中，rdr1基因均无表达，32例卵巢癌中，mdr1表达阳性率为28．1％，mdr1基因表达与病理类型有关（P＜0．05），而且mdr1表达阳性者耐药发生率（55．6％）显著高于阴性者（8．6％，P＜0．01）。结果提示：卵巢癌中隐含有由mdr1介导的多药耐药机制,mdr1的表达与卵巢癌的化疗耐药有一定的关系。
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| 关 键 词： | 卵巢癌 多药耐药基因 表达 |
Expression of Multidrug Resistance Gene in Ovarian Cancer |
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| Zhang Fan,Chen Huizheng,Liu Shiquan,et al Zhongnan Hospital Wuhan University,Wuhan.Expression of Multidrug Resistance Gene in Ovarian Cancer[J].Journal of New Medicine,2001,11(2):80-81. |
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| Authors: | Zhang Fan Chen Huizheng Liu Shiquan Zhongnan Hospital Wuhan University Wuhan |
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| Institution: | Zhang Fan,Chen Huizheng,Liu Shiquan,et al Zhongnan Hospital Wuhan University,Wuhan 430071 |
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| Abstract: | To inverstigate the potential drug resistance mechanism and the possible contribution of the multidrug resistance phenotype to chemoresistance in ovarian cancer, the mdr 1 gene expression was analyzed by using the RT-PCR technique in 7 cases of normal ovary and 32 cases of ovarian carcinoma. Results showed that mdr 1 gene was expressed in 9 cases (28.1%) with ovarian carcinoma,but negative expression in normal ovary tissues was found. The expression of mdr 1 gene was associated with histologic type (P<0.05). The patients with mdr 1 had much higher resistance rate (55.6%) than that of mdr 1- cases (8.6%) to chemotherapy. The results suggested that the expression of mdr 1 gene might contribute to drug resistance in ovarian carcinomas. |
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| Keywords: | Ovarian cancer Multidrug resistance gene Expression |
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