晚发性维生素K缺乏症致颅内出血的临床研究

目的探讨晚发性维生素K缺乏症致颅内出血的发病影响因素及临床特征。方法对125例晚发性维生素K缺乏症致颅内出血患儿的临床特征进行回顾性分析。结果性别、喂养方式、地域差异、肝功能异常、巨细胞病毒感染、维生素K预防性注射与晚发性维生素K缺乏症致颅内出血关系密切。结论加强婴儿混合喂养,维生素K预防性注射,加强农村婴儿特别是男性婴儿的营养监测,对晚发性维生素K缺乏症患儿进行肝功能和巨细胞病毒抗体检查,并辅以护肝治疗等全面综合治疗,是预防晚发性维生素K缺乏症致颅内出血的必要手段。

Intracranial hemorrhage due to late onset vitamin K deficiency

Objective To discuss the clinical characteristic and the inducing factors of intracranial hemorrhage caused by late onset vitamin K deficiency.Methods 125 infants with intracranial hemorrhage due to late onset vitamin K deficiency were reviewed and analyzed.Results The sex,feeding patterns,inhabiting area,hepatic function abnormality,CMV infection,and prophylactic injection of vitamin K were closely related to the intracranial hemorrhage caused by late onset vitamin K deficiency.Conclusion Mixing feeding in infants,prophylactic administration of vitamin K,nutritional surveillance on infants especially male infants in rural areas,detection of hepatic function and CMV anti-body,as well as liver-protecting treatments are essential to prevent intracranial hemorrhage caused by late onset vitamin K deficiency.