| 间接性TMJ创伤后髁突软骨中IL-6的表达及其意义 |
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| 引用本文： | 胡开进,周树夏,戴毅敏,程晓兵,孙庆妹. 间接性TMJ创伤后髁突软骨中IL-6的表达及其意义[J]. 医学争鸣, 2002, 23(3): 193-195 |
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| 作者姓名： | 胡开进 周树夏 戴毅敏 程晓兵 孙庆妹 |
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| 作者单位： | 第四军医大学口腔医学院颌面外科,陕西,西安,710033;第四军医大学口腔医学院病理科,陕西,西安,710033 |
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| 基金项目： | 陕西省科学技术研究发展计划项目 ( 2 0 0 0 K14 -G13) |
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| 摘 要： | 目的 通过观察羊颞颌关节（TMJ）间接性创伤后不同时期髁突软骨中IL－6的表达，探讨IL－6在TMJ创伤后导致TMJ骨关节病过程中的作用。方法 用自制撞击装置造成山羊双侧颞颌关节间接性创伤，分别于伤后2h,7d,1mo和3ml取材，并以正常TMJ作为对照，用免疫组化法进行观察。结果 TMJ创伤后髁突软骨中IL－6的表达明显强于正常对照组，其着色程度越靠近结构破坏区越明显。结论 IL－6在TMJ创伤后导致TMJ骨关节病过程中起重要作用。
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| 关 键 词： | 颞颌关节 损伤 白细胞介素-6 免疫组化 |
| 文章编号： | 1000-2790(2002)03-0193-03 |
| 修稿时间： | 2001-05-09 |
Expression of interleukin-6 in the condyle of temporomandibular joint after indirect trauma |
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| HU Kai-Jin,ZHOU Shu-Xia,DAI Yi-Min,CHENG Xiao-Bing,Sun Qing-Mei. Expression of interleukin-6 in the condyle of temporomandibular joint after indirect trauma[J]. Negative, 2002, 23(3): 193-195 |
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| Authors: | HU Kai-Jin ZHOU Shu-Xia DAI Yi-Min CHENG Xiao-Bing Sun Qing-Mei |
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| Abstract: | AIM In order to understand the roles of interleukin 6 (IL 6) in the pathogenesis of temporomandibular joint (TMJ) after indirect trauma. METHODS Trauma to the TMJ of goats were achieved under an impact to the right and left mandibular angle with self made device. The goats were killed after 2 h, 7 d, 1 mo and 3 mo. The Expression of interleukin 6 in the condyle of TMJ was observed by immunohistochemical staining, the normal TMJ were used as controls. RESULTS The positive expression of IL 6 was observed in the condyle of TMJ after indirect trauma, the stronger expression was found in the destroyed area of condyle. CONCLUSION IL 6 plays an important role in the pathogenesis of TMJ after indirect trauma. |
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| Keywords: | temporomandibular joint trauma immunohistochemistry interleukin 6 |
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