| 氯霉素氢化可的松乳膏的制备及质量控制 |
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| 引用本文： | 方焱,张善堂,陈象青,肖明,屈建. 氯霉素氢化可的松乳膏的制备及质量控制[J]. 中国药房, 2007, 18(16): 1245-1246 |
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| 作者姓名： | 方焱 张善堂 陈象青 肖明 屈建 |
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| 作者单位： | 安徽省立医院药剂科,合肥市,230001 |
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| 摘 要： | 目的:制备氯霉素氢化可的松乳膏并建立其质量控制方法。方法:以水包油基质制备乳膏;采用高效液相色谱法测定其中主药含量。结果:所制制剂各项检查均符合2005年版《中国药典》相关规定;氯霉素、氢化可的松线性范围分别为50.10～400.80(r=0.9997)、25.08～200.64μg.mL-1(r=0.9997);平均回收率分别为100.5%(RSD=2.1%)、100.4%(RSD=1.7%)。结论:本制剂制备工艺简便可行,质量稳定可控。
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| 关 键 词： | 氯霉素氢化可的松乳膏 制备 质量控制 |
| 文章编号： | 1001-0408（2007）16-1245-02 |
| 收稿时间： | 2006-11-30 |
| 修稿时间： | 2006-11-302007-03-14 |
Preparation and Quality Control of Chloramphenicol and Hydrocortisone Cream |
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| FANG Yan,ZHANG Shantang,CHEN Xiangqing,XIAO Ming,QU Jian. Preparation and Quality Control of Chloramphenicol and Hydrocortisone Cream[J]. China Pharmacy, 2007, 18(16): 1245-1246 |
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| Authors: | FANG Yan ZHANG Shantang CHEN Xiangqing XIAO Ming QU Jian |
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| Abstract: | OBJECTIVE:To prepare chloramphenicol and hydrocortisone cream and to establish a method for its quality control.METHODS:The cream was prepared with O/W as base.The content of the cream was derermiend by HPLC.RESU_ LTS:The prepared cream was up to the standard stated in China Pharmacopeia.The linear range of chloramphenicol vs.hydro_cortisone was 50.10～400.80(r=0.999 7)vs.25.08～200.64μg·mL-1(r=0.999 7),and the average recoveries were 100.5%(RSD=2.1%)and 100.4%(RSD=1.7%),respectively.CONCLUSION:The preparation process of chloramphenicol and hydrocortisone cream is simple and its quality is stable and controllable. |
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| Keywords: | Chloramphenicol and hydrocortisone cream Preparatlon Quallty control |
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