疏肝益阳胶囊治疗勃起功能障碍的作用机理研究

目的 :研究疏肝益阳胶囊的药理作用和机理。方法 :通过观察疏肝益阳胶囊对大、小鼠阴茎勃起潜伏期、扑捉潜伏期、射精潜伏期、扑捉次数、射精次数、前列腺、精囊、睾丸、提肛肌、胸腺的重量 ,血清睾酮水平以及游泳耐力和抗缺氧能力的影响。通过构建恒河猴勃起功能障碍模型 ,观察疏肝益阳胶囊对性行为、阴茎血流和阴茎肌电图的影响。结果 :疏肝益阳胶囊可显著缩短去势大鼠阴茎勃起潜伏期、扑捉潜伏期、射精潜伏期 ,增加扑捉次数、射精次数 ,增加小鼠前列腺、精囊、睾丸、提肛肌重量及血清睾酮水平 ,减少小鼠胸腺的重量。并可改善恒河猴模型的性欲、正常勃起和射精次数。缩小阴茎静脉管腔直径及减慢阴茎静脉回流速度。而阴茎勃起外周神经诱发电位波幅和潜伏期无变化。结论 :疏肝益阳胶囊可显著改善勃起功能 ,并可同时改善性欲及射精功能、提高抗疲劳能力。其机理与提高雄激素、促肾上腺皮质激素水平和缩小阴茎静脉管腔直径及减慢阴茎静脉回流速度有关。

Study of Shugan Yiyang capsule on erectile dysfunction

Objective: To study the pharmacological effect of Shugan Yiyang(SGYY) capsule. Method: kongming mice and Wistar rats were used to observe the effects of SGYY capsule on sexual desire,erection, ejaculation. and fatigue. The weight of prostate, seminal vesicle, testes, levators and thymus and serum testosterone level were also measured. Furthermore, Rhesus monkey were used to construct animal model of erectile dysfunction. Effects of SGYY capsule on sexual behavior, penile blood flow and electromyogram were observed. Result: SGYY capsule can remarkably reduce the incubation period of erection, ejaculation and innovate the sexual desire,erection, ejaculation both on rats and rhesus monkeys. The weight of prostate, seminal vesicle, testes, levators in mice and serum testosterone level of rats increased while the weight of thymus decreased. It can also diminish the luminar of vein and reduce the venous outflow while the transmission of peripheral nervous system remained stable. Conclusion: SGYY capsule can remarkably improve the erectile activity, sexual desire and ejaculatory activity. The mechanism of SGYY capsule may be related to the increase of androgen and adrenocorticohormone levels. as well as the reduction of penile venous outflow.