银杏叶提取物改善L-甲状腺素诱导的大鼠心肌缺血/再灌注损伤

目的 研究银杏叶提取物对L-甲状腺素诱导的心肌肥厚合并缺血/灌注引起的心律失常的保护作用.方法 SD大鼠分为5个组,分别为正常组,模型组,倍他乐克(10mg/kg·d-1)组,银杏叶提取物高、低(100、50 mg/kg·d-1)剂量组,按0.4 mg/g·d-1皮下注射L-甲状腺素10d造模,同时灌胃给药治疗.在第1...

Cardiac Arrhythmia Induced by Ischemia/reperfusion was Improved with Ginkgo biloba Extract(EGb)

Objective To observe therapeutic effect of Ginkgo biloba extract （EOb） on arrhythmia in levothyroxine induced hypertrophy with ischemia/reperfusion. Methods The rats were divided into 5 groups： normal, model, metoprolol （10 mg/kg·d^-1）, EGbh, EGbl （100, 50 mg/kg·d^-1）, EGb and metoprolol wore glven through intragastric administration for 10 days. The models were induced subcutaneously by levothyroxine （0.4mg/ kg·d^-1 ×10d）, On ilst day, all the animals were iigated on left coronary artery for 10 min and then reperfusion for 10 rain, Results Egb and metoprolol showed anti-hypertrophy and anti-arrhythmla effects and deereased the occurrence rates of arrhythmia significantly. In models serum CK, CKMB, LDH, HBDH and AST were elevated, EGb and metoprolol attenuated them, Ventricular weight index was increased in models and ameliorated by metoprolol and EGb significantly, Conclusion Cardiac arrhythmia induced by ischemia/reperfusion was improved with EGb.