激光心肌血管重建术对犬缺血心肌血流量和氧代谢的影响

目的　探讨激光心肌血管重建术（TMLR）对急性缺血心肌血流量和氧代谢的作用与机制。方法　18只犬随机等分为正常对照组、心肌缺血组、激光治疗组。采用连续型Nd∶YAG激光行TMLR。测左前降支冠状动脉（LAD）结扎前、结扎后30min和60min的心肌血流量（MBF），动脉血氧含量（C

The Effect of TMLR onMyocardial Blood Flow and Myocardial Oxygen Metabolism in Ischemic Myocardium of Dogs

Objective　To investigate the effect and mechanism of transmyocardial laser revascularizationMethods　18 adult dogs were randomly and evenly divided into the cont rol, ischemic and TMLR groups. Continuous wave Nd∶YAG laser was used to TML R. The parameters included myocardial blood flow (MBF), concentration of oxygen in the blood of artery and coronary sinus (Ca.O2 ＆ Ccs.O2）, myocar dial oxygen uptake （MVO2）and myocardial oxygen extraction（MEO2）before an d 30 min and 60 min after ligation of ligating the left anterior descending coro nary artery (LAD).Results　(1) In the ischemic and the TMLR groups, MBF 30 min after th e LAD ligation were 39.06 ml±5.33 ml／(100 g myocardium*min) and 51.35 ml± 3.42 ml／(100 g myocardium*min) (P＜0.05), respectively , MBF 60 min after the LAD ligation were 35.77 ml±8.23 ml／(100 g myocardium * min) and 52.18 ml±4.82 ml／(100 g myocardium* min) (P＜0.05), respectively. (2) In the ischemic and the TMLR groups, Ccs.O 2 60 min after the LAD ligation were 7.35 ml/dl±1.47 ml/dl and 5.82 ml±1.84 ml /dl (P＜0.05), MVO2 30 min after the LAD ligation were 2.95 ml ±1.35 ml／(100 g myocardium* min) and 4.42 ml±1.04 ml／(100 g myocardium* min) (P＜0.05), respectively, MVO2 60 min after the LA D ligation were 2.35 ml±1.10 ml／(100 g myocardium*min) and 4.38±0.93 ml ／(100 g myocardium*min) (P＜0.05), respectively, and M EO2 60 min after the LAD ligation were (44.83±9.83)% and (59.33±10.07)% (P＜0.05), respectively.Conclusions　TMLR may effectively improve myocardial blo od flow and myocardial oxygen metabolism in acute myocardial ischemia.