AUTONOMIC REFLEXES AND THE CARDIOVASCULAR EFFECTS OF PROPYLENE GLYCOL |
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Authors: | AL-KHUDHAIRI, D. WHITWAM, J. G. |
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Affiliation: | Department of Anaesthetics Royal Postgraduate Medical School, Du Cane Road, London W12 0HS. |
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Abstract: | The effect of i.v. propylene glycol in doses of 160800mg kg1. on heart rate, arterial pressure and efferentsympathetic activity were observed in anaesthetized paralysed,artificially ventilated dogs. Within 35 s of the commencementof the injection of propylene glycol there was an immediatemean decrease in heart rate of 22.7 and 72.1 beat min1and in arterial pressure of 27.2 and 58.8 mm Hg at doses of400 mg kg1 and 800 mg kg1, respectively, togetherwith a gross reduction of sympathetic activity and a subsequentincrease in heart rate above control values. All these effectswere transient and at a dose of propylene glycol 800 mg kg1,heart rate and arterial pressure returned to control valuesby 1 min, and sympathetic activity by 2 min. Blocking the vagusnerves with atropine prevented the observed changes in heartrate and arterial pressure, whereas sympathetic blockade withbretylium tosylate had little effect. It was concluded thatpropylene glycol causes powerful reflex stimulation of the cardiomotorvagus and transient inhibition of efferent sympathetic activitywithin 5 s of injection, and that the origin of the reflex islikely to be intrathoracic. |
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