| STR基因座在湖北土家族人群多态性研究 |
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| 引用本文： | 蒋飞,杜春玲,孙萍,王栋梅.STR基因座在湖北土家族人群多态性研究[J].郧阳医学院学报,2010,29(1):34-36. |
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| 作者姓名： | 蒋飞 杜春玲 孙萍 王栋梅 |
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| 作者单位： | 蒋飞(郧阳医学院附属太和医院呼吸内科,湖北 十堰 442000;郧阳医学院附属太和医院门诊部,湖北 十堰 442000);杜春玲(郧阳医学院附属太和医院呼吸内科,湖北 十堰,442000);孙萍,王栋梅(郧阳医学院附属太和医院门诊部,湖北 十堰,442000) |
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| 摘 要： | 目的:对湖北土家族群体D3S1358、THO1、D21S11、D18S51、PentaE、PentaD、VWA、D8S11798个STR基因座的遗传多态性进行群体遗传学研究。方法:利用荧光标记复合扩增及毛细管电泳自动荧光检测的方法,对226例无关个体的8个STR基因座进行检测。结果:在湖北土家族人群中8个STR基因座个人识别率为0.843～0.981,多态性信息含量为0.66～0.90。所有基因座经卡方检验符合Hardy-Weinberg平衡。结论:上述8个STR基因座在湖北土家族人群中等位基因分布较好,个体识别率高,可用于人类遗传分析及法医学中的亲子鉴定和个体识别。
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| 关 键 词： | 短串联重复序列 复合扩增 群体遗传学 |
Gene Polymorphism of 8 STRs locus in Hubei Tujia Nationality |
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| JIANG Fei,DU Chun-ling,SUN Ping,WANG Dong-mei.Gene Polymorphism of 8 STRs locus in Hubei Tujia Nationality[J].Journal of Yunyang Medical College,2010,29(1):34-36. |
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| Authors: | JIANG Fei DU Chun-ling SUN Ping WANG Dong-mei |
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| Institution: | JIANG Fei1,2,DU Chun-ling1,SUN Ping2,WANG Dong-mei2 (1Department of Respiratory Medicine,2Department of Outpatient,Taihe Hospital,Yunyang Medical College,Shiyan,Hubei 442000,China) |
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| Abstract: | Objective To investigate the gene polymorphism of eight short tandem repeats(STR) locus D3S1358,THO1,D21S11,D18S51,PentaE,PentaD,VWA,D8S1179 on population genetics in Tujia nationality of Hubei province. Methods Totally 226 unrelated individuals from Tujia nationality of Hubei province were enrolled and eight STR locus were detected with fluorescent labelling multiplex amplification and capillary electrophoresis.Results The polymorphic information content(PIC) of 8 locus were ranged from 0.66 to 0.90 and di... |
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| Keywords: | Short tandem repeat Multiplex Amplification Population genetics |
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