| 粘附分子在复发性口腔溃疡的发病机制中作用的探讨 |
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| 引用本文： | 孙睿,董玙,晁海英,孙晓震. 粘附分子在复发性口腔溃疡的发病机制中作用的探讨[J]. 实用口腔医学杂志, 2003, 19(4): 301-303 |
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| 作者姓名： | 孙睿 董玙 晁海英 孙晓震 |
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| 作者单位： | 1. 兰州医学院第二附属医院口腔科,730030
2. 太原山西省中医药研究所骨科 |
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| 摘 要： | 目的：探讨可溶性血管内皮细胞粘附分子(sVCAM-1)、可溶性细胞间粘附分子(sICAM-1)在复发性口腔溃疡(recurrent oral ulceration，ROU)发病机制中的作用。方法：采用双抗体夹心酶联免疫吸附实验法检测血清中的sVCAM-1、sICAM-1浓度。结果：ROU患者的sVCAM-1浓度高于健康对照组，差异有显著性。ROU患者的sICAM-1浓度与健康对照组相比无显著性差异。sVCAM-1、sICAM-1两者浓度在活动期与静止期差异无显著性。结论：sVCAM-1在复发性口腔溃疡发病机制中可能有重要意义。
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| 关 键 词： | 复发性口腔溃疡 发病机制 粘附分子 可溶性血管内皮细胞粘附分子 可溶性细胞间粘附分子 |
| 文章编号： | 1001-3733(2003)-046-0301-03 |
| 修稿时间： | 2002-08-12 |
Expression of vascular cell adhesion molecule-1 in recurrent oral ulceration |
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| Sun Rui,Dong Yu,Chao Haiying,et al.. Expression of vascular cell adhesion molecule-1 in recurrent oral ulceration[J]. Journal of Practical Stomatology, 2003, 19(4): 301-303 |
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| Authors: | Sun Rui Dong Yu Chao Haiying et al. |
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| Affiliation: | Sun Rui,Dong Yu,Chao Haiying,et al. Department of Stomatology,2nd Hospital of Lanzhou Medical College,Lanzhou 730030 |
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| Abstract: | Objective: To study the effects of soluble vascular endothelial cell adhesion molecule-1(sVCAM-1) and soluble intercellular adhesion molecule-1 (sICAM-1) in recurrent oral ulceration (ROU). Methods: sVCAM-1 and sICAM-1 in oral menbrane tissue sampls were measured with an enzyme linked immunosorbent assay using sandwich technices in 45 patients with ROU and 40 nomal controls. Results: The expression level of sVCAM-1 in the oral membrane tissue samples of ROU patients was higher than that in the controls (P<0.05). sICAM-1 expression in patients were similar to that in the control(P>0.05). Both sVCAM-1 and sICAM-1 expression were not significantly different with the stages (ROU-active and ROU-free) of the lesion. Conclusion: sVCAM-1 might play a role in ROU. |
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| Keywords: | Aphthous stomatitis Vascular cell adhesion molecule-1 Enzyme-linked immunosorbent assay |
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