| 纳米粒穿透血脑屏障机制的研究进展 |
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| 引用本文： | 林晓宁,田新华.纳米粒穿透血脑屏障机制的研究进展[J].中国新药杂志,2008,17(21). |
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| 作者姓名： | 林晓宁 田新华 |
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| 作者单位： | 厦门大学附属中山医院神经外科,厦门,361004 |
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| 摘 要： | 血脑屏障(blood-brain barrier,BBB)的存在使98%的药物无法进入脑组织,是制约神经系统药物发展的重要因素.纳米粒载药系统能够透过BBB,并提高脑内药物浓度,是实现脑内靶向给药的良好载体,但其透过BBB的机制至今尚未完全明白.自从2001年Kreuter提出关于纳米粒(nanoparticles,NP)透过BBB的6点可能机制后,针对此机制并进而提高载药NP入脑效率的探讨已成为热点之一,文中就目前NP穿透BBB机制研究进展做一综述.
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| 关 键 词： | 纳米粒 血脑屏障 靶向药物 药物载体 中枢神经系统 |
Progress in mechanisms of nanoparticles across the blood-brain barrier |
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| LIN Xiao-ning,TIAN Xin-hua.Progress in mechanisms of nanoparticles across the blood-brain barrier[J].Chinese Journal of New Drugs,2008,17(21). |
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| Authors: | LIN Xiao-ning TIAN Xin-hua |
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| Institution: | Department of Neurosurgery;Zhongshan Hospital of Xiamen University;Xiamen 361004;China |
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| Abstract: | The existence of blood-brain barrier(BBB) makes it impossible for 98% medicines to enter the brain.This is an important restrictive factor for the development of central nervous drugs.By nanoparticle delivery system,drugs can cross the BBB and increase the drug concentration in brain.This system is a better carrier for drugs to target brain,but the mechanism how it permeate the BBB is not completely understood.Since Kreuter proposed six plausible mechanisms for nanoparticles(NP) across the BBB in 2001,it ha... |
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| Keywords: | nanoparticles blood-brain barrier drug targeting drug carriers central nervous system |
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