| Abstract: | Dogs undergoing renal allografts were treated with phytohemagglutinin-M (PHA-M) with and without azathioprine before and after transplantation. PHA-M treatment was associated with histological evidence of decreased renal allograft rejection and minimal azotemia. PHA-M-treated animals had marked leukocytosis postoperatively and, unlike untreated control animals or azathioprine-treated dogs, had sustained elevations in total lymphocyte levels. However, PHA-M treatment did not decrease survival due to associated drug toxicity manifested by a distemper-like syndrome not observed in other concurrently evaluated animals. |
