参麦注射液雾化吸入对放射性肺炎患者血清C-反应蛋白和体液免疫功能变化的影响

目的:参麦注射液雾化吸入对放射性肺炎患者血清C-反应蛋白(CRP)和体液免疫功能变化的影响。方法:选取2013年12月—2014年10月本院收治的50例放射性肺炎患者,随机分为实验组和对照组各25例。实验组在同期治疗的基础上雾化吸入参麦注射液。分别对50例患者于治疗前后各采血1次,并测定血清CRP及体液免疫中Ig G,Ig A,Ig M,C3的浓度。根据放射性肺炎的急性放射性损伤(RTOG)分级标准将50例患者进行分级。结果:两组患者的血清CRP水平均可见不同程度下降,而实验组经雾化吸入参麦注射液后血清CRP下降更为明显,差异有统计学意义(P0.05),治疗后对照组与实验组血清CRP值经对比有显著差异(P0.05)。经放射性肺炎的RTOG分级标准将患者进行分级后,可知血清CRP值与放射性肺炎严重程度呈正相关(r=0.72,P0.05)。将两组患者治疗前后的Ig G,Ig A,Ig M的浓度进行对比,差异有统计学意义(P0.05),实验组经治疗后,补体C3浓度显著升高,对照组变化不明显,两组的差异经对比有统计学意义(P0.05)。结论:雾化吸入参麦注射液可显著减轻患者临床症状,降低肺炎患者炎症反应水平,改善患者机体的免疫状态,增强机体免疫功能。

Study on Changes of Humoral Immune Function and CRP of Patients with Radiation Pneumonitis by Shenmai Injection Atomization Inhalation

Objective: To investigate the effect of Shenmai injection atomization inhalation on serum C- reactive protein(CRP)in patients with radiation pneumonitis effect changes and humoral immune function. Method: Fifty cases of radiation pneumonia were selected and randomly divided into experimental group and control group with 25 cases in each group. The experimental group in the same period of treatment on inhalationof Shenmai injection, the control group without drug. Each of the 50 patients before and after treatment the blood sampling time, concentration and determination of CRP and humoralimmune serum IgG, IgA, IgM, C3. According to the rating of acute radiation injury(RTOG) grading standard of radiation pneumonia 50 cases patients were graded. Result: CRP levels in two groups of patients showed varying degrees of decline,while the experimental group after inhalation of Shenmai injection of serum CRP decreased more significantly, the difference was statistically significant (P < 0.05). After the treatment,control group and experimental group serum CRP value by comparison has the remarkable difference (P<0.05). The acute radioactive lung injury classification stadard(RTOG) grading standards of radiation pneumonia will be gradedpatients, know the value of serum CRP and radioactive pneumonia was positively correlated with the severity of (r=0.72, P<0.05). Comparing the two groups before and after treatment in patients with the concentration of IgG, IgA, IgM, the difference was statistically significant(P<0.05), the experimental group after the treatment, the concentration of complement C3 increased significantly in control group did not change significantly, the differences between these two groups by comparison with statistical significance (P<0.05). Conclusion: Inhalation of Shenmai injection can significantly reduce the clinical symptoms,reduce the inflammation reaction in patients with pneumonia level, improve body immune state of patients, enhance the immune function of organism.