新生儿窒息血清总胆汁酸变化观察

目的分析新生儿窒息后血清总胆汁酸（TBA）变化及其临床意义。方法检测92例窒息新生儿和19例无窒息史正常新生儿的血清TBA、总胆红素（TBIL）、直接胆红素（DBIL）、丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）、碱性磷酸酶（ALP）和γ-谷氨酰转移酶（γ-GT）。结果窒息组血清TBA及其他肝功能指标（TBIL、DBIL、ALT、AST、ALP、γ-GT），与正常对照组比较均无显著性差异（P均〉0.05）。轻度窒息组与重度窒息组比较，轻度窒息组和重度窒息组分别与对照组比较，差异也均无显著性（P均〉0.05）。结论血清TBA与新生儿窒息及其窒息程度无明显关系。

Significance of variations of serum total bile acid in 92 eases asphyxiul neonates

Objective To analyse the change in the quantity of serous total bile acid （TBA） in asphyxia] neonates and its clinical significance. Methods The quantity of serous total bile acid （TBA）,total bilirubin （TBIL）,direct hiliruhin（DBIL）, alanine aminotransferase（ALT）,aspartate amino transferase（AST）, alkaline phosphatase（ALP） and γ-glutamyltransferase（γ-GT） in 92 cases asphyxial neonates and in 19 cases of control group were determined. Results There were no significant differences in the quantity of serous TBA and other liver function index （TBIL, DBIL, ALT,AST,ALP, γ-GT） between the asphyxial neonates group and the control group （P〉0.05）.There also no significant differences between the seriously asphyxial group and the slightly asphyxial group,between the slightly asphyxial group and the control group（P〉0.05）. Conclusion The quantity of serous total bile acid is not signifcandy correlated to neonates asphyxiate and the degree of asphyxia.