血必净注射液治疗脓毒性休克的临床研究

目的探讨血必净注射液治疗脓毒性休克的临床价值。方法选取2009年3月-2012年3月我院52例脓毒性休克患者，观察使用血必净注射液(观察组33例)与未使用血必净注射液(对照组19例)患者的临床疗效及预后情况。结果治疗后观察组HR、体温及WBC明显低于对照组，两组患者治疗后AST、ALT、BUN及Cr水平均有明显下降，观察组治疗72h后AST、ALT、BUN及Cr水平均明显低于对照组；两组患者治疗后PaO2、PaCO2及PaO2/FiO2水平均有明显上升，观察组水平明显高于对照组(P<0.05)；观察组死亡率9.1%，明显低于对照组的47.7%。结论血必净注射液治疗脓毒性休克具有菌、毒、炎症介质并治的作用，对降低死亡率、改善预后有积极意义。

Clinical research on Xuebijing injection on septic shock

Objective To investigate the clincial value of Xuebiqing on the treatment of septic shock. Methods Select 52 cases of septic shock treated in the hospital from March 2009 to March 2012. Observations were done about the clincial efficacy and prognosis condtions of patients treated with Xuebijing injection（the observation group with 33 cases） and those not treated with Xuebijing injection（the control group with 19 cases）. Results After treatment, the HR, temperature and WBC of the observation group were significantly lower than those of the control group（P〈0.05）. After treatment for 72 hours, the AST, ALT, BUN and Cr of the observation group were significantly lower than those of the control group（P〈0.05）. After treatment, the levles of PaO2, PaCO2 and PaOJFiO2 of the observation group were significantly higher than those of the control group（P〈0.05）. The mortality of the observation group was 9.1%, significantly lower than 47.7% of the control group（P〈0.01）. Conclusion While treating septic shock, Xuebijing injection has the integrated effects on bacteria, poisons and inflammatory mediators, and impose positive significance on decreasing mortality and improving prognosis.