泛福舒预防慢性阻塞性肺疾病急性加重的临床观察

目的观察细菌溶解产物(泛福舒)防治慢性阻塞性肺疾病急性加重期(AECODP)的疗效。方法 76例AECODP患者随机分为两组各38例,对照组给予常规抗炎、平喘、化痰及其对症治疗,观察组在常规治疗基础上给予泛福舒口服;观察并比较两组患者1年内急性发作次数、抗生素使用时间、外周血T淋巴细胞亚群和血清免疫球蛋白的变化。结果观察组1年内急性发作次数、急性发作期间抗生素使用时间均较对照组缩短(P<0.01),观察组6个月后外周血T淋巴细胞亚群以及IgG、IgA水平与治疗前比较差异有统计学意义(P<0.05),对照组治疗前后比较差异无统计学意义(P>0.05)。结论应用细菌溶解产物治疗可明显改善慢性阻塞性肺疾病的免疫功能,减少感染急性发作次数。

Clinical research on bacterial lysates in prevention of acute exacerbation of chronic obstructive pulmonary diseases

Objective To observe the preventive effects of bacterial lysates for acute exacerbation of chronic obstructive pulmonary diseases（AECOPD）. Method 75 patients with AECOPD were randomly divided into two groups.. 38 cases in control group were given conventional anti-inflammatory, relieving asthma, resolving phlegm and symptomatic treatment, The observation group 38 cases on the basis of routine treatment for bacterial lysates to oral~ Observation of 2 groups of patients within 1 years the number of acute attack, antibiotic use time, peripheral blood T lymphocyte subgroups and serum immunoglobulin changes, and compare. Results The observation group 1 years the number of acute attack, during an acute episode of antibiotics use time are shorter than in control group（P〈0.01）, The observation group 6 months after peripheral blood T lymphocyte subsets and IgG, IgA levels before and after treatment had significant difference（P〈0.05）, The control group before and after treatment there was no statistically significant difference（P〉0.05）. Conclusion Application of bacterial lysates to treatment could obviously improve the chronic obstructive pulmonary disease immune function, reduce the infection of acute episodes.