应用ROC曲线评价中性粒细胞CD64诊断儿童化脓性脑膜炎的价值

目的应用受试者工作特征曲线(ROC曲线)评价中性粒细胞CD64诊断儿童化脓性脑膜炎的价值.方法选取40例经脑脊液证实的化脓性脑膜炎儿童患者,所有患者均检测中性粒细胞的CD64、CD11b及血常规.选取20例健康体检患儿,并测试中性粒细胞的CD64、CD11b.结果 CD64、CD11b诊断化脓性脑膜炎的ROC曲线下面积分别是0.880,0.853;CD64、CD11b诊断化脓性脑膜炎的最佳阈值为1.30,15.85;CD64、CD11b诊断化脓性脑膜炎的灵敏度分别为88.3%、70.4%、特异度分别为90.4%、75.9%;化脓性脑膜炎患者中性粒细胞CD64、CD11b与白细胞计数无相关性(P>0.05).结论 ROC曲线评价显示中性粒细胞CD64对化脓性脑膜炎具有较高的诊断准确度,CD64是诊断化脓性脑膜炎理想的敏感指标.

Diagnostic Value of Neutrophil CD64 Using ROC Curve in bacterial meningitis

Objective To evaluate the value Neutrophil CD64 in the diagnosis of bacterial meningitis by Receiver Operating Characteristic curves（ROC）. Methods 40 patients with bacterial meningitis（confirmed by cerebrospinal fluid） were obtained for CD64 and CDllb, measurement, blood routin test. 20 non-infected, healthy children cases were seted as control group. Their Mood samples were obtained for CD64 and CDllb. Results Draw the ROC curve of the levels of CD64, CDllb in diagnosing bacterial meningitis. The area under the ROC curve were 0.880, 0.853, The best cutoff value of CD64, CDllb were 1.30, 15.85% the sensitivity were 88.3%, 70.4%, the specificity were 90.4%, 75.9%; The coefficients between CD64 and WBC, CDllb and WBC were 0.284, 0.293（P〉0.05）, no liner correlation. Conclusion ROC analysis showed that Neutrophil CD64 for the bacterial meningitis diagnosis has higher diagnostic accuracy, CD64 is an ideal diagnostic marker to early identify bacterial meningitis.