口腔疣状癌伴灶性鳞癌颈淋巴结转移灶裸鼠移植瘤模型的建立 |
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引用本文: | 王月红,陈明伟,唐瞻贵,刘欧胜,方小丹,全宏志.口腔疣状癌伴灶性鳞癌颈淋巴结转移灶裸鼠移植瘤模型的建立[J].上海口腔医学,2010,19(1). |
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作者姓名: | 王月红 陈明伟 唐瞻贵 刘欧胜 方小丹 全宏志 |
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作者单位: | 1. 中南大学湘雅医院·口腔医学院口腔颌面外科,湖南,长沙,410078 2. 中南大学湘雅医院·口腔医学院口腔颌面外科,湖南,长沙,410078;山东省济宁市第一人民医院口腔科,山东,济宁,272000 |
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基金项目: | 国家自然科学基金(30872895); 湖南省科技厅科技计划重点项目(2008FJ2011); 湖南省博士后基金(2006FJ4246)~~ |
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摘 要: | 目的:建立口腔疣状癌伴灶性鳞癌颈淋巴结转移灶移植瘤原代模型,探讨建立模型的方法.方法:将口腔疣状癌伴灶性鳞癌颈淋巴结转移组织,通过组织块皮下接种法建立颈部淋巴结转移灶模型.观察其生长状况,对移植瘤、裸鼠肝、肾、肺及淋巴结行系列检查并与来源肿瘤组织进行比较.结果:成瘤率87.5%(7/8),移植瘤具有来源肿瘤组织类似的形态学特征,肝、肾、肺未见转移,腋下及腹股沟淋巴结反应性增生.结论:通过组织块皮下接种法,成功建立了口腔疣状癌伴灶性鳞癌颈淋巴结转移灶移植瘤原代模型.
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关 键 词: | 口腔疣状癌 移植瘤 裸鼠 动物模型 |
Establishment of xenografted model of oral verrucous carcinoma with focal squamous cell carcinoma metastasizing to the cervical lymph nodes in nude mice |
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Abstract: | PURPOSE: To use the excised cervical lymph node tissue from oral verrucous carcinoma patient with focal squamous cell carcinoma subcutaneously to establish a xenografted model in nude mice. METHODS: The xenograft tumors were finally removed for histopathological study and the mice were laparotomized to examine metastatic tumors in livers, kidneys, lungs. RESULTS: The tumor formation rate was 87.5%(7/8),and the appearance of transplanted tumors was like that in human and HE staining showed that the cancer ce... |
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Keywords: | Oral verrucous carcinoma Xenografted model Nude mice Animal model |
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