PTHrP inhibits BMP-6 expression through the PKA signaling pathway in breast cancer cells |
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| Authors: | Dong Mi Ming Zhang Ji-dong Yan Jie Zhang Xu Wang Qing Wang Shuang Yang Tian-hui Zhu |
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| Affiliation: | (1) Laboratory of Molecular Genetics, Medical College, Nankai University, Tianjin, 300071, People’s Republic of China; |
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| Abstract: | Background PTHrP, a mediator of humoral hypercalcemia of malignancy, is considered as a potential activator to induce breast cancer cells metastasizing to bone. However, recent clinical evidences and basal research results prove that PTHrP expression in primary tumors indicates good prognosis. BMP-6, as a member of TGF-β superfamily, is closely correlated with tumor differentiation and skeletal metastasis. |
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