| 1,1-二烷基-4-(3-溴丙酰基)-哌嗪溴化物的合成及生物活性研究 |
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| 引用本文： | 李润涛,曹胜利,陈恒昌,杨锦宗,蔡孟深.1,1-二烷基-4-(3-溴丙酰基)-哌嗪溴化物的合成及生物活性研究[J].药学学报,1996,31(10):757-760. |
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| 作者姓名： | 李润涛 曹胜利 陈恒昌 杨锦宗 蔡孟深 |
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| 作者单位： | [1]北京医科大学药学院 [2]郑州大学化学系 |
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| 摘 要： | 设计合成了七种新的1,1-二烷基-4-(3-溴丙酰基)哌嗪季铵盐溴化物,通过IR,1HNMR和元素分析证实其结构。初步生物活性试验结果表明,Ⅵa,Ⅵc和Ⅵe～g有明显的镇痛活性,Ⅵe～g还有较好的抗氧化SOD活性,但未发现有抗肿瘤作用。
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| 关 键 词： | 哌嗪季铵盐溴化物 镇痛活性 抗氧化SOD活性 |
| 收稿时间： | 1995-08-21 |
SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF 1,1-DIALKYL-4(3-BKOMOPROPIONYL)PIPERAZINIUM BROMIDES |
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| RT Li,SL Cao,HC Chen,JZ Yang and MS Cai.SYNTHESIS AND PHARMACOLOGICAL ACTIVITIES OF 1,1-DIALKYL-4(3-BKOMOPROPIONYL)PIPERAZINIUM BROMIDES[J].Acta Pharmaceutica Sinica,1996,31(10):757-760. |
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| Authors: | RT Li SL Cao HC Chen JZ Yang and MS Cai |
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| Abstract: | Seven new 1,1-dialkyl-4-(3-bromopropionyl)piperazinium bromides were synthesized.Their structures were elucidated by IR,1H NMR and elemental analysis.The compounds were screened for antitumor,analgesic and antioxide SOD activities。Though none of them showed antitumor activity,most of them shawed distinct analgesic activity and antioxide SOD activity. |
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| Keywords: | Piperazinium bromide Analgesic activity Antioxide SOD activity |
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