O,O′-二烷基-O″-(取代苯乙腈肟)磷酸酯、硫代磷酸酯的合成及对氯硝柳胺的灭螺增效作用

合成了20个O,O′-二烷基-O″-(取代苯乙腈肟)磷酸酯、硫代磷酸酯,并分别与杀螺剂氯硝柳胺组成复方,进行室内杀螺试验。初步结果表明,化合物V_4,7,12,18有明显杀螺增效作用,其中V12可使氯硝柳胺的杀螺效果提高3.81倍。同时发现化合物V_2,7,10,13单独使用时,也有良好的杀螺作用。

SYNTHESIS OF O, O'-DIALKYL-O"-(SUBSTITUTED PHENYLGLYOXYLONITRILE OXIMINO)PHOSPHATES AND THIOPHOSPHATES AND THEIR SYNERGISTIC ACTION WITH NICLOSAMIDE AS MOLLUSCICIDE

Twenty compounds of O,O'-dialkyl-O"-(substituted phenylglyoxylonitrileoximino) phosphates and thiophosphates were prepared.The screening tests showed that compoundsV_4,7,12,18 combined with niclosamide exhibited significant molluscicidal synergism against snails(Oncomelania hupensis hupensis).The LC₅₀ of niclosamide alone and V₁₂ combined with niclosamide(1:1)against snail was 0.0820 mg·L^-1 and 0.0215 mg·L^-1,respectively. The molluscicidalactivity of the latter was 3.81 times that of niclosamide alone.The compounds V_{2,7, 10,13} appeared tohave high molluscicidal activity.