| 消旋15(R)-15-甲基PGE2甲酯的合成 |
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| 引用本文： | 金碧燕,吴元鎏,张守仁,徐瑞明.消旋15(R)-15-甲基PGE2甲酯的合成[J].药学学报,1996,31(10):795-797. |
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| 作者姓名： | 金碧燕 吴元鎏 张守仁 徐瑞明 |
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| 作者单位： | 中国医学科学院,中国协和医科大学药物研究所 |
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| 摘 要： | d,l-15(R)-15-Methyl-PGF2α methyl ester 11-trimethylsilyl ether(II)wasprepared from selective monosilylation of d,l-15(R)-15-methyl-PGF2αmethyl ester(I) withtrimethylsilyldiethylamine in acetone. Oxidation of(II ) with Collin's reagent gave d,l-15(R)-15-methyl-PGE2 methyl ester 11-trimethylsilyl ether(III)which,without purification,was converted to d,l-15(R)-15-methyl-PGE2 methyl ester(IV)under mild acidic conditions.
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| 关 键 词： | 前列腺素合成 15-甲基PGE_2甲酯 抗胃溃疡 |
| 收稿时间： | 1996-03-28 |
SYNTHESIS OF d,l-15(R)-15-METHYL-PGE2 METHYL ESTER |
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| BY Jin,YL Wu,SR Zhang and RM xu.SYNTHESIS OF d,l-15(R)-15-METHYL-PGE2 METHYL ESTER[J].Acta Pharmaceutica Sinica,1996,31(10):795-797. |
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| Authors: | BY Jin YL Wu SR Zhang and RM xu |
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| Abstract: | d,l-15(R)-15-Methyl-PGF2α methyl ester 11-trimethylsilyl ether(II)wasprepared from selective monosilylation of d,l-15(R)-15-methyl-PGF2αmethyl ester(I) withtrimethylsilyldiethylamine in acetone. Oxidation of(II ) with Collin's reagent gave d,l-15(R)-15-methyl-PGE2 methyl ester 11-trimethylsilyl ether(III)which,without purification,was converted to d,l-15(R)-15-methyl-PGE2 methyl ester(IV)under mild acidic conditions. |
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| Keywords: | 15-Methyl-PGE2 methyl ester Antigastric ulcer Prostaglandin synthesis |
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