巴曲酶对急性心肌缺血犬冠脉节段阻力和流量的影响

犬冠状动脉定量狭窄造成急性心肌缺血,观察巴曲酶(batroxobin)对冠脉循环及血流动力学的影响。结果显示,batroxobin可剂量依赖性地增加缺血心脏冠脉血流量,2BU·kg^-1(0.1BU·kg^-1·min^-1)iv后40min,缺血犬冠脉流量比盐水对照组增加12%,此时小冠脉阻力由4.1±0.5降至3.2±0.5mmHg·min·ml^-1,而大冠脉阻力无明显变化;给药后120min,上述作用仍然持续,且冠脉总阻力降低13%,左室压上升及下降最大速率与盐水对照组相比分别增大14%和16%。结果表明,batroXobin在冠脉低灌流状态下仍可降低小冠脉阻力,增加冠脉流量,这可能是其改善缺血犬冠状循环及心脏功能的机理之一。

THE EFFECT OF BATROXOBIN ON CORONARY SEGMENTAL RESISTANCE AND CORONARY BLOOD FLOW IN ACUTE MYOCARDIAL ISCHEMIC DOGS

To study the effects of batroxobin on coronary circulation and cardiac performancein acute myocardial ischemia,Batroxobin was given intravenously to dogs with experimental coronarystenosis.A dose-dependent increase of coronary blood flow(CBF)was observed.Forty minutes afterbatroxobin(2 BU·kg^-1 at infusion rate 0.1 BU·kg^-1·min^-1)administration,CBF increased by12%(P<0.05),small coronary resistance(R_S)decreased from 4.1±0.5 to 3.2±0.5 mmHg·min·ml^-1(P<0.01),while large coronary resistance(R_L)changed insignificantly from 3.9±0.8 to 3.8±0.7mmHg·min·ml^-1(P>0.05).Two hours following drug administration,the changes in CBF, R_S and R_L still remained and R_T decreased by 13%(P<0.05).The + LV(dp/dt)_max and -LV(dp/dt)maxincreased by 14% and 16%(P<0.05)respectively compared with those in control group.It isconcluded that batroxobin improves the ischemic canine coronary circulation and cardiac performanceby way of lowering the small coronary resistance and thus increasirig CBF.The data also suggest thebenificial effect of batroxobin in acute myocardial ischemia.