| 烟酰胺类和吡啶丙烯酰胺类衍生物的合成及扩血管活性 |
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| 引用本文： | 傅焕建,朱莉亚,林紫云. 烟酰胺类和吡啶丙烯酰胺类衍生物的合成及扩血管活性[J]. 药学学报, 1996, 31(9): 715-720 |
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| 作者姓名： | 傅焕建 朱莉亚 林紫云 |
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| 作者单位： | 中国医学科学院,中国协和医科大学药物研究所 |
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| 摘 要： | Eighteen nicotinamides(I1～12)and pyridylacrylamides(II1～15)have beensynthesized. All synthesized amides were submitted to phannacological screening and 0.1um·L-1(10-7M)-noradrenaline induced contraction of the rat aortic strip was taken aS criterion,The amidesI3,4 and II1,2 showed more potent vasodilating activity than compounds I12,13 and II3,4.
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| 关 键 词： | 烟酰胺 吡啶丙烯酰胺 扩血管活性 |
| 收稿时间： | 1995-12-08 |
SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIES |
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| HJ Fu,LY Zhu and ZY Lin. SYNTHESIS OF NICOTINAMIDE AND PYRIDYLACRYL AMIDE DERIVATIVES AND STUDIES ON THEIR VASODILATION ACTIVITIES[J]. Acta pharmaceutica Sinica, 1996, 31(9): 715-720 |
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| Authors: | HJ Fu LY Zhu ZY Lin |
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| Abstract: | Eighteen nicotinamides(I1～12)and pyridylacrylamides(II1～15)have beensynthesized. All synthesized amides were submitted to phannacological screening and 0.1um·L-1(10-7M)-noradrenaline induced contraction of the rat aortic strip was taken aS criterion,The amidesI3,4 and II1,2 showed more potent vasodilating activity than compounds I12,13 and II3,4. |
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| Keywords: | Pyridylacrylamides Vatalilation Nicotinamides |
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