| 双部位吸收模型拟合吉非贝齐在人体中药代动力学数据 |
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| 引用本文： | 刘晓东,谢林,王进,周云曙,王真,刘国卿. 双部位吸收模型拟合吉非贝齐在人体中药代动力学数据[J]. 药学学报, 1996, 31(10): 737-741 |
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| 作者姓名： | 刘晓东 谢林 王进 周云曙 王真 刘国卿 |
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| 作者单位： | 中国药科大学药代动力学研究中心 |
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| 摘 要： | 测定了8名受试者po吉非贝齐(Gem)600mg后血药浓度一时间数据,观察到血药浓度双峰现象。建立一种双部位吸收药动学模型拟合这些数据,实验值与拟合值吻合好,r2均大于0.99。相应参数如下:Tmax1.10±0.46h;Tmax32.60±0.73h;Cmax113.62±4.3μg·ml-1);Cmax217.22±3.83μg·ml-1);T10.06±0.06h;T21.42±0.57h;T31.79±0.60h。
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| 关 键 词： | 药代动力学 吉非贝齐 双部位吸收 |
| 收稿时间： | 1995-11-10 |
TWO-SITE ABSORPTION MODEL FITS FO PHARMACOKINETIC DATA OF GEMFIBROZIL IN MAN |
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| XD Liu,L Xie,J Wang,YS Zhou,Z Wang and GQ Liu. TWO-SITE ABSORPTION MODEL FITS FO PHARMACOKINETIC DATA OF GEMFIBROZIL IN MAN[J]. Acta pharmaceutica Sinica, 1996, 31(10): 737-741 |
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| Authors: | XD Liu L Xie J Wang YS Zhou Z Wang GQ Liu |
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| Abstract: | The plasma concentration-time data of gemfibrozil in 8 male subjects weredetermined after an oral dose of 600 mg.Two-peak concentrations in plasma were observed.A kind ofone-compartment model with two-sites of drug absorption was proposed and used to fit these data。Agood agreement between observed and predicted data was found in all subjects with correlation indexes(γ2)>0.99.The corresponding pharmacokinetic parameters were estimated as follows:Tmax1,1.10±0.46h;Tmax2,2.60±0.73h;Cmax1,13.62±4.30μg·ml-1;Cmax2,17.22±3.83μg·ml-1;T1,0.06±0.06h;T2,1.42±0.57h and T3,1.79±0.60 h. |
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| Keywords: | Pharmacokinetics Gemfibrozil Two-sites drug absorption |
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