| HPLC测定卡肌宁注射液中阿曲库铵苯磺酸盐异构体及相关杂质 |
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| 引用本文： | 韩俊,曾焕俊,方镇文.HPLC测定卡肌宁注射液中阿曲库铵苯磺酸盐异构体及相关杂质[J].药学学报,1996,31(10):775-779. |
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| 作者姓名： | 韩俊 曾焕俊 方镇文 |
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| 作者单位： | 广州市药品检验所，广东药学院 |
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| 摘 要： | 在InertsilODS柱上,以乙腈一氯化四丁基铵(TBAC)体系为流动相,HPLC法同时分离阿曲库铵苯磺酸盐异构体及相关杂质,考察了色谱填料及流动相中乙腈量、氯化四丁基铵浓度及pH值对色谱保留的影响。该法用于卡肌宁注射液的质量控制和稳定性的初步考察,取得满意效果。
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| 关 键 词： | 卡肌宁 阿曲库铵苯磺酸盐 高效液相色谱法 |
| 收稿时间： | 1995-12-07 |
HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY OF ATRACURIUM BESILATE ISOMERS AND ITS RELATED IMPURITIES IN TRACRIUM INJECTION |
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| J Han,HJ Zeng and ZW Fang.HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY OF ATRACURIUM BESILATE ISOMERS AND ITS RELATED IMPURITIES IN TRACRIUM INJECTION[J].Acta Pharmaceutica Sinica,1996,31(10):775-779. |
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| Authors: | J Han HJ Zeng and ZW Fang |
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| Abstract: | A new HPLC method for simultaneous determination of three isomers of atracuriumbesilate and its related impurities in tracrium injection(a preparation of atracurium besilate supplied byBurroughs Wellcome Co)is described on an ODS column with acetonitrile—tetrabutylammoniumchloride solution(14:86)as mobile phase. The influence of acetonitrile,tetrabutylammonium chlorideand pH on the chromatographic retention behavior of these compounds was also investigated.Gcodseparation and assay results have been obtained using the described method. |
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| Keywords: | Tracrium Atracurium besilate HPLC |
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