腹腔静脉联合化疗对老年进展期结肠癌临床疗效观察

目的：观察腹腔静脉联合化疗对老年进展期结肠癌的临床疗效。方法：腹腔静脉联合化疗组40例采用氟脲苷、喜树碱腹腔化疗联合草酸铂、氟脲苷、CF静脉滴注方案，静脉化疗组40例采用草酸铂、氟脲苷、CF静脉滴注方案，4wk为一疗程，连用6个疗程，然后评定疗效。结果：腹腔静脉联合化疗组40例，总有效率为65．0％，无进展中位生存期14．3个月；静脉联合化疗组总有效率为42．5％，无进展中位生存期10．8个月。两组有效率差异有统计学意义（P〈0．05），联合化疗组无进展中位生存期优于对照组（P〈0．05）。结论：腹腔静脉联合化疗是治疗老年进展期结肠癌的一种安全、有效的方法。

Observation of the clinical efficacy of the intraperitoneal combined with intravenous chemotherapy for the elder patients with advanced colon cancer

Objective:To investigate the clinical efficacy of intraperitoneal combined with intravenous chemo- therapy in the treatment of elderly patients with advanced colon cancer.Methods:Forty patients in the combined chemo- therapy group were given fluorouracil and camptothecin intraperitoneally combined with intravenous infusion of oxaliplatin, fluorouracil,and calcium folinate.Forty patients in intravenous chemotherapy group were administered oxaliplatin,flu- orouracil,and calcium folinate intravenously.Four weeks as one cycle and six cycles were repeated.The clinical efficacy was evaluated.Results:The overall response rate was 65.0% in the combined chemotherapy group and 42.5% in the intravenous chemotherapy group.The progression-free median survival period was 14.3 months in the combined chemo- therapy group and 10.8 months in the intravenous chemotherapy group.The difference was significant between the two groups (P<0.05).Conclusion:Intraperitoneal combined with intravenous chemotherapy was safe and effective in the treatment of elderly patients with advanced colon cancer.