| 肿瘤转移相关蛋白在甲状腺乳头状腺癌伴淋巴结转移组织中的原位表达研究 |
| |
| 引用本文： | 范松青,魏启幼,伍海南,钱仲裴.肿瘤转移相关蛋白在甲状腺乳头状腺癌伴淋巴结转移组织中的原位表达研究[J].中国现代医学杂志,1998(7). |
| |
| 作者姓名： | 范松青 魏启幼 伍海南 钱仲裴 |
| |
| 作者单位： | 湖南医科大学附属第二医院病理科 |
| |
| 摘 要： | 利用免疫组化ＡＢＣ法，研究甲状腺乳头状腺癌，甲状腺腺瘤和正常甲状腺组织中的肿瘤转移相关基因蛋白ＣＤ４４ｖ６，ＥＧＦＲ，转移抑制基因ｎｍ２３－Ｈ１和抑癌基因ｐ５３蛋白的原位表达。结果发现ＣＤ４４ｖ６和ＥＧＦＲ表达上调与肿瘤转移密切相关（Ｐ＜０．０５，Ｐ＜０．０１），而ｎｍ２３－Ｈ１的表达与肿瘤转移抑制密切相关（Ｐ＜０．０１）。这提示肿瘤转移相关基因和转移抑制基因之间的表达失衡是甲状腺乳头状腺癌易发生转移的重要原因。
|
| 关 键 词： | 甲状腺肿瘤，转移相关基因蛋白，免疫组织化学 |
FZPRESSION OF TUMOR METASTASIS -RELATED GENE PROTEIN IN PAPILLARY THYROID CARCINOMA WITH LYMPH NODE METASTASIS |
| |
| Fan singqing, Wei Qiyou, Wu Hainan,et al..FZPRESSION OF TUMOR METASTASIS -RELATED GENE PROTEIN IN PAPILLARY THYROID CARCINOMA WITH LYMPH NODE METASTASIS[J].China Journal of Modern Medicine,1998(7). |
| |
| Authors: | Fan singqing Wei Qiyou Wu Hainan |
| |
| Institution: | Fan singqing, Wei Qiyou, Wu Hainan,et al . |
| |
| Abstract: | CD44v6,EGFR,nm23- H1 and p53 protein expression were studied in 84 cases of papillary thyroid carcinoma using ABC immunohis - tochemical method. Results show that CD44v6 , EFGR expression significantly posiively correlated with lymph node metastasis of papillary thyroid carcinoma(P<0.05,P<0.01). A higMynegative association observed between nm23-H1 expression and lymph node metastis(P<0.01). This suggests that an unbalanced expression of metastasis related-genes and metastasis suppressor -genes is an impor- tant cause of papillary thyroid carcinoma and permits lymph node metastasis. |
| |
| Keywords: | Thyroid neoplasm : Metastasis related gene protein Immunohistochemistry |
| 本文献已被 CNKI 等数据库收录！ |
