| 血红素氧合酶-1与心血管疾病研究 |
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| 引用本文： | 汪红霞,黄维义,魏宗德. 血红素氧合酶-1与心血管疾病研究[J]. 国外医学:内科学分册, 2007, 34(1): 6-9,56 |
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| 作者姓名： | 汪红霞 黄维义 魏宗德 |
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| 作者单位： | 泸州医学院附属医院心内科,四川泸州646000 |
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| 摘 要： | 血红素氧合酶-1(HO-1)是血红素氧合酶的诱导型,能催化血红素分解生成CO、胆红素和铁.这三种代谢产物通过多种机制对心血管系统产生保护作用,包括抗氧化应激、抗炎症损伤、抗细胞增殖、抗凋亡、抑制血小板聚集、调节血管张力及参与细胞内信号传递等.HO-1在多种心血管疾病中均有适应性表达,并在防治这些心血管疾病方面发挥重要作用.
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| 关 键 词： | 血红素氧合酶-1 一氧化碳 胆红素 心血管疾病 |
| 文章编号： | 1004-2369（2007）01-0006-04 |
| 修稿时间： | 2006-05-202006-09-20 |
The study of heme oxygenase-1 and cardiovascular disease |
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| WANG Hong-xia,HUANG Wei-yi,WEI Zong-de. The study of heme oxygenase-1 and cardiovascular disease[J]. Foreign Medical Sciences(Section of Internal Medicine), 2007, 34(1): 6-9,56 |
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| Authors: | WANG Hong-xia HUANG Wei-yi WEI Zong-de |
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| Affiliation: | Department of Cardiology, The Affiliated Hospital, Luzhou Medical University, Luzhou 646000, China |
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| Abstract: | Heme oxygenase-1(HO-1) is an inducible isoform of heme oxygenase,it can degrade heme into carbon monoxide,bilirubin and iron.These metabolic products protect the cadiovascular system via many mechanisms,including anti-oxidative stress,anti-inflammation injury,anti-proliferation of cells,anti-apoptosis,supressing platelet aggregation,regulating the tension of vessels and participating in the intracellular signal transduction,etc.HO-1 exhibits its adaptive expression in many cadiovascular diseases,and play an important part in the prevention and cure of them. |
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| Keywords: | Heme oxygenase-1 Carbon monoxide Bilirubin Cadiovascular disease |
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