| 以病原菌群体感应系统为靶标的新型抗菌药物的研究进展 |
| |
| 作者姓名： | Yin SL Chang YJ Deng SP Wang QC Yu WG Gong QH |
| |
| 作者单位： | 中国海洋大学医药学院海洋药物教育部重点实验室; |
| |
| 基金项目： | 国家高技术研究发展计划(863计划)资助项目(2007AA09Z418); 中国海洋大学海洋药物教育部重点实验室开放基金资助项目(KLMD(OUC)200806) |
| |
| 摘 要： | 近年来,日益严重的细菌耐药性成为全球关注的焦点,尤其是南亚发现的新型超级细菌几乎对绝大多数抗生素都具有抗性,在世界范围内引起了恐慌。对病原菌致病机制的研究发现,许多病原菌的致病机制都依赖细菌群体感应系统的调节和控制。筛选高效的群体感应抑制剂有望成为解决细菌感染以及耐药性问题的一个有效途径。本文主要阐述了细菌群体感应信号调控系统、群体感应抑制因子体外筛选模型及体内动物模型评价,群体感应抑制因子的研究近况等内容。
|
| 关 键 词： | 细菌耐药性 新型抗菌药物 群体感应 |
Research progress of new antibacterial drugs that target bacterial quorum sensing systems |
| |
| Yin SL,Chang YJ,Deng SP,Wang QC,Yu WG,Gong QH.Research progress of new antibacterial drugs that target bacterial quorum sensing systems[J].Acta Pharmaceutica Sinica,2011,46(6):613-621. |
| |
| Authors: | Yin Shou-Liang Chang Ya-Jing Deng Su-Ping Wang Qing-Chi Yu Wen-Gong Gong Qian-Hong |
| |
| Institution: | YIN Shou-liang,CHANG Ya-jing,DENG Su-ping,WANG Qing-chi,YU Wen-gong,GONG Qian-hong*(Key Laboratory of Marine Drugs,Ministry of Education,College of Medicine and Pharmacy,Ocean University of China,Qingdao 266003,China) |
| |
| Abstract: | In recent years,antibiotic resistance of bacteria has become a global health crisis.Especially,the new class of superbug was found in South Asia,which is resistant to almost known antibiotics and causes worldwide alarm.Through the underlying mechanisms of bacterial pathogenecity,the expression of many pathogen virulence factors is regulated by the process of quorum sensing.Screening efficient quorum sensing inhibitors is an especially compelling approach to the future treatment of bacterial infections and a... |
| |
| Keywords: | antibiotic resistance new antibacterial drug quorum sensing |
| 本文献已被 CNKI PubMed 等数据库收录！ |
|
