| EV71非结构蛋白的结构和功能及其为靶点的药物研究进展 |
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| 引用本文： | Qin XY,Lin L,Yang Y,Zhang SX,Kong JQ,Cheng KD,Zhao YF,Wang W. EV71非结构蛋白的结构和功能及其为靶点的药物研究进展[J]. 药学学报, 2011, 46(7): 753-761 |
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| 作者姓名： | Qin XY Lin L Yang Y Zhang SX Kong JQ Cheng KD Zhao YF Wang W |
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| 作者单位： | 曲阜师范大学生命科学学院;中国医学科学院北京协和医学院药物研究所卫生部天然药物生物合成重点实验室天然药物活性物质与功能国家重点实验室; |
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| 基金项目： | 国家科技重大专项综合平台炎症及免疫性疾病药效评价研究平台(2009ZX09301-003-13) |
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| 摘 要： | 近年肠道病毒71型(EV71)等引起的手足口病在中国大陆呈现上升的流行趋势,其正链的RNA基因组翻译成一个多聚蛋白,进一步自剪切为结构蛋白和非结构蛋白;随着研究的深入,非结构蛋白在病毒生命周期中的功能逐一被鉴定,本文就EV71非结构蛋白的结构功能及针对这些靶点的抗病毒药物进行综述。
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| 关 键 词： | 肠道病毒71型 非结构蛋白 抗EV71药物 |
Advances in functional studies of nonstructural proteins and development of antiviral agents for enterovirus 71 |
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| Qin Xian-Yun,Lin Lin,Yang Yan,Zhang Shu-Xiang,Kong Jian-Qiang,Cheng Ke-Di,Zhao Yun-Feng,Wang Wei. Advances in functional studies of nonstructural proteins and development of antiviral agents for enterovirus 71[J]. Acta pharmaceutica Sinica, 2011, 46(7): 753-761 |
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| Authors: | Qin Xian-Yun Lin Lin Yang Yan Zhang Shu-Xiang Kong Jian-Qiang Cheng Ke-Di Zhao Yun-Feng Wang Wei |
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| Affiliation: | QIN Xian-yun1,2,LIN Lin1,YANG Yan2,ZHANG Shu-xiang2,KONG Jian-qiang2,CHENG Ke-di2,ZHAO Yun-feng1,WANG Wei2(1.College of Life Science,Qufu Normal University,Qufu 273165,China,2.Institute of Materia Medica,Chinese Academy of Medical Sciences & Peking Union Medical College,Key Laboratory of Biosynthesis of Natural Products,Ministry of Health of PRC,State Key Laboratory of Bioactive Substances and Functions of Natural Medicines,Beijing 100050,China) |
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| Abstract: | Human enterovirus 71(EV71) is one of the major etiological agents for the hand,foot,and month disease(HFMD) and is causing frequent,widespread occurrence in the mainland of China.The single positive-stranded RNA genome of EV71 is translated into a single polyprotein which is autocleavaged into structural and nonstructural proteins.The functions of many nonstructural proteins characterized in the life cycle of virus are potential targets for blocking viral replication.This article reviews the studies of the ... |
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| Keywords: | enterovirus 71 nonstructural protein antiviral drugs against EV71 |
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