| 抗肿瘤热敏靶向脂质体的研究进展 |
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| 引用本文： | Chen J. 抗肿瘤热敏靶向脂质体的研究进展[J]. 药学学报, 2011, 46(5): 502-506 |
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| 作者姓名： | Chen J |
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| 作者单位： | 南京中医药大学药学院药剂学教研室; |
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| 基金项目： | 江苏省青蓝工程资助项目 |
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| 摘 要： | 脂质体具有靶向传递药物进入肿瘤部位的优势,被广泛用于肿瘤的临床治疗,但是靶向传递并不能保证药物在肿瘤部位被生物利用。为了解决此问题,热敏靶向脂质体(TTL)已经成为目前的研究热点。TTL既能提高药物在肿瘤部位的浓度,又能在加热条件下触发释放所载药物,从而显著改善所载药物的抗肿瘤效果。本文主要综述了近年来该领域的研究进展。
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| 关 键 词： | 脂质体 靶向给药 抗肿瘤药物 触发释放 |
Development of targeting thermosensitive liposomes for tumor treatment |
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| Chen Jun. Development of targeting thermosensitive liposomes for tumor treatment[J]. Acta pharmaceutica Sinica, 2011, 46(5): 502-506 |
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| Authors: | Chen Jun |
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| Affiliation: | CHEN Jun(Department of Pharmaceutics,College of Pharmacy,Nanjing University of Chinese Medicine,Nanjing 210046,China) |
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| Abstract: | Liposomes which offer the advantage of the enhanced drug accumulation at tumor sites are currently applied extensively in the clinical treatment of tumor.However,accumulation of the liposomes in the tumor area cannot guarantee the drug bioavailability.To resolve the question,thermosensitive targeting liposomes(TTL) have been the hotspot of current studies.TTL can enhance drug accumulation at tumor sites and be triggered to release their contents upon hyperthermia.By applying these two strategies,antitumor e... |
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| Keywords: | liposome drug targeting antitumor drug triggered release |
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