| 2株B群脑膜炎奈瑟菌的分子生物学分析 |
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| 引用本文： | 万强,吴隽,周海健. 2株B群脑膜炎奈瑟菌的分子生物学分析[J]. 预防医学论坛, 2011, 0(6) |
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| 作者姓名： | 万强 吴隽 周海健 |
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| 作者单位： | 大连市疾病预防控制中心;中国疾病预防控制中心传染病预防控制所; |
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| 摘 要： | [目的]探讨分离自大连市开发区2005年和2008年外来人口中2例暴发型脑膜炎死亡病例2株B群脑膜炎奈瑟菌的分子生物学特征及其关联性。[方法]2010年,对2株B群流脑菌株进行脉冲场电泳(PFGE)和多位点序列分型(MLST)分型分析。[结果]2株菌PFGE型相似性为100%,应为同一来源;MLST分析结果均为ST5662型。菌株对青霉素、头孢类、阿齐霉素、氯霉素、利福平等多种抗菌药物敏感。[结论]2株B群脑膜炎奈瑟菌分子分型结果一致,为同一科隆。
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| 关 键 词： | B群脑膜炎奈瑟菌 脉冲场凝胶电泳(PFGE) 多位点序列分析 |
Typing Of Two Neisseria Meningitidis Serogroup B Strains Isolated with Molecular Biology |
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| WAN Qiang,WU Jun,ZHOU Hai-jian.. Typing Of Two Neisseria Meningitidis Serogroup B Strains Isolated with Molecular Biology[J]. Preventive Medicine Tribune, 2011, 0(6) |
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| Authors: | WAN Qiang WU Jun ZHOU Hai-jian. |
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| Affiliation: | WAN Qiang,WU Jun,ZHOU Hai-jian.(Dalian City Center for Disease Control and Prevention,Dalian,116021,Liaoning,China) |
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| Abstract: | [Objective] To study the homology of 2 strains of group B Neisseria meningitidis isolated from suspicious meningitis death cases in 2005 and 2008.[Methods]Two strains of group B of Nesseria meningitis isolated were molecularly typed by pulsed-field gel electrophoresis(PFGE) and multilocus sequence typing analysis(MLST) after serological differentiation in 2010.[Results]The strains of group B of Nesseria meningitis shared the same pulsed-field gel electrophoresis patterns from the same clone,indicating that ... |
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| Keywords: | Serogroup B Neisseria meningitides Pulsed-field gel electrophoresis |
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