克山病心肌细胞线粒体钙化及其发病机理探讨

本文应用电镜在18例急型及亚急型克山病心肌线粒体发现结晶、颗粒、不定等三型内含物。前两型为磷酸钙,选择性沉着于凝固性肌溶灶之线粒体;后一型为线粒体变性产物,分布广泛。这提示,钙化的心肌细胞,其质膜有损害,线粒体有呼吸功能,肌浆 Ca~(2 )浓度异常增高具有反复性。因此探讨膜损害及线粒体钙化机理,治疗上采用钙拮抗剂和膜保护剂具有重要意义。

Mitochondrial calcification and its pathogenesis of the myocardial cells in Keshan diseas

The electron microscopic observations on the myocardium of 18 cases with thekeshan disease were disclosed that intra-mitochondrial inclusions occurring inmyocardial cells of the foci of coagulative myocytolysis might be classified intothree types:1.crystalline,that is the precipitate of calcium phosphate;2.granular,in which its granular compounds exhibit the crystallinity,being alsocalcium phosphate;3.amorphous,which have the ability to concentrate calci-um to the point of mitochondrial calcification,being products of mitochondrialdegeneration.The fundamental cause of mitochondrial calcification,chiefly be-ing the crystalline type,was high activity of the respiratory chain,over-load-ing of calcium in the sarcoplasm caused by the primary damage of sarcolemma,and inconsecutive precipitations of calcium caused by repeated action of causativefactor.