| 2-芳基丙酸类药物的立体选择性药效学及药动学 |
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| 引用本文： | 石劲敏,邓巧琳,李端.2-芳基丙酸类药物的立体选择性药效学及药动学[J].中国药理学通报,2003,19(4):379-383. |
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| 作者姓名： | 石劲敏 邓巧琳 李端 |
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| 作者单位： | 1. 上海市药品检验所药理室,上海,200233
2. 复旦大学药学院药理学教研室,上海,200032 |
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| 摘 要： | 2 芳基丙酸类衍生物或称为洛芬类 ,包括布洛芬、萘普生、氟比洛芬和依托度酸等 ,是非甾体类抗炎药物中十分重要的一类药物。这类药物几乎全部是以消旋体形式上市的 ,而两个对映体间的药理活性、作用机制及毒理又存在很大不同。正是由于洛芬类药物所表现的丰富生物特性以及这些特性对于临床用药的指导作用 ,从而使得这类药物倍受关注。该文主要阐述以氟比洛芬为代表的洛芬类药物在药理学上的立体选择性
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| 关 键 词： | 2-芳基丙酸类药物 立体选择性 药效学 药动学 |
| 文章编号： | 1001-1978(2003)04-0379-05 |
| 修稿时间： | 2002年9月23日 |
Enantioselective pharmacodynamics and pharmacokinetics of the 2-arylpropionic acid derivatives |
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| SHI Jing Min,DENG Qiao Lin ,LI Duan.Enantioselective pharmacodynamics and pharmacokinetics of the 2-arylpropionic acid derivatives[J].Chinese Pharmacological Bulletin,2003,19(4):379-383. |
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| Authors: | SHI Jing Min DENG Qiao Lin LI Duan |
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| Institution: | SHI Jing Min,DENG Qiao Lin 1,LI Duan 1 |
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| Abstract: | The 2 arylpropionic acid derivatives, or "profens", are an important group of nonsteroidal antiinflammatory drugs (NSAIDs). Widely used members of this group include ibuprofen, naproxen, flurbiprofen, and etodolac. Most of these drugs were marketed as racemates, however the individual enantiomers differ in their pharmacological activity, mechanism and toxicity. This drug class is widely focused because of its various biologic properties that affect their clinical use. This review will demonstrate enantioselective pharmacodynamics and pharmacokinetics of "profens". |
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| Keywords: | arylpropionic acid derivatives enantioselective pharmacodynamics pharmacokinetics |
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