| 醋氯芬酸缓释片的研制及释药性质 |
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| 引用本文： | 张秀芝 盛云仙. 醋氯芬酸缓释片的研制及释药性质[J]. 中国医药工业杂志, 1997, 28(9): 403-406 |
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| 作者姓名： | 张秀芝 盛云仙 |
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| 作者单位： | 中国药科大学医药化工研究所 |
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| 摘 要： | 为了减轻醋氯芬酸对胃肠道的刺激作用和副作用，减少服药次数，利用其几乎不溶于水的特性，制成亲水性凝胶骨架片。通过测定制剂的体外溶出度评价了该缓释片的处方，结果表明该制剂的体外溶出行为符合Ｈｉｇｕｃｈｉ方程，处方Ｒ４具有较好的缓释效果。
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| 关 键 词： | 醋氯芬酸 缓释片 溶出度 释药动力学 |
PREPARATION AND RELEASE PROPERTIES OF SUSTAINED RELEASED ACECLOFENAC TABLETS |
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| ZHANG Xiu Zhi ,SHENG Yun Xian,WU Bao Jin,ZHANG Jin Ping,YANG Chao Fang. PREPARATION AND RELEASE PROPERTIES OF SUSTAINED RELEASED ACECLOFENAC TABLETS[J]. , 1997, 28(9): 403-406 |
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| Authors: | ZHANG Xiu Zhi SHENG Yun Xian WU Bao Jin ZHANG Jin Ping YANG Chao Fang |
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| Affiliation: | ZHANG Xiu Zhi *,SHENG Yun Xian,WU Bao Jin,ZHANG Jin Ping,YANG Chao Fang |
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| Abstract: | Aceclofenac Sustained released tablets were prepared on the basis of the releasing mechanism of the gel matrix systems,and evaluated by the basket dissolution method. The results showed that the dissolution behavior of the tablets followed Higuchi kinetics. Formulation R 4 had good slow releasing rate. |
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| Keywords: | aceclofenac slow releasing tablets dissolution release kinetics |
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